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식물 노화·수명 연구단
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Comprehensive data resources and analytical tools for pathological association of aminoacyl tRNA synthetases with cancer

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Title
Comprehensive data resources and analytical tools for pathological association of aminoacyl tRNA synthetases with cancer
Author(s)
Lee, JH; You, S; Hyeon, DY; Byeongsoo Kang; Kim, H; Park, KM; Han, B; Daehee Hwang; Kim, S
Publication Date
2015-03
Journal
DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION, v.2015, no., pp.bav022 -
Publisher
OXFORD UNIV PRESS
Abstract
Mammalian cells have cytoplasmic and mitochondrial aminoacyl-tRNA synthetases (ARSs) that catalyze aminoacylation of tRNAs during protein synthesis. Despite their housekeeping functions in protein synthesis, recently, ARSs and ARS-interacting multifunctional proteins (AIMPs) have been shown to play important roles in disease pathogenesis through their interactions with disease-related molecules. However, there are lacks of data resources and analytical tools that can be used to examine disease associations of ARS/AIMPs. Here, we developed an Integrated Database for ARSs (IDA), a resource database including cancer genomic/proteomic and interaction data of ARS/AIMPs. IDA includes mRNA expression, somatic mutation, copy number variation and phosphorylation data of ARS/AIMPs and their interacting proteins in various cancers. IDA further includes an array of analytical tools for exploration of disease association of ARS/AIMPs, identification of disease-associated ARS/AIMP interactors and reconstruction of ARS-dependent disease-perturbed network models. Therefore, IDA provides both comprehensive data resources and analytical tools for understanding potential roles of ARS/AIMPs in cancers
URI
http://pr.ibs.re.kr/handle/8788114/2090
DOI
10.1093/database/bav022
ISSN
1758-0463
Appears in Collections:
Center for Plant Aging Research (식물 노화·수명 연구단) > Journal Papers (저널논문)
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