BROWSE

Related Scientist

Researcher

분자활성 촉매반응 연구단
분자활성 촉매반응 연구단
more info

Efficient synthesis of frutinone A and its derivatives through palladium-catalyzed C-H activation/carbonylation

Cited 14 time in webofscience Cited 0 time in scopus
192 Viewed 6 Downloaded
Title
Efficient synthesis of frutinone A and its derivatives through palladium-catalyzed C-H activation/carbonylation
Author(s)
Yongje Shin; Changho Yoo; Youngtaek Moon; Yunho Lee; Sungwoo Hong
Publication Date
2015-04
Journal
CHEMISTRY-AN ASIAN JOURNAL, v.10, no.4, pp.878 - 881
Publisher
WILEY-V C H VERLAG GMBH
Abstract
Frutinone A, a biologically active ingredient of an antimicrobial herbal extract, demonstrates potent inhibitory activity towards the CYP1A2 enzyme. A three-step total synthesis of frutinone A with an overall yield of 44 is presented. The construction of the chromone-annelated coumarin core was achieved through palladium-catalyzed C-H carbonylation of 2-phenolchromones. The straightforward synthetic route allowed facile substitutions around the frutinone A core and thus rapid exploration of the structure-activity relationship (SAR) profile of the derivatives. The inhibitory activity of the synthesized frutinone A derivatives were determined for CYP1A2, and ten compounds exhibited one-to-two digit nanomolar inhibitory activity towards the CYP1A2 enzyme. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
URI
https://pr.ibs.re.kr/handle/8788114/2065
ISSN
1861-4728
Appears in Collections:
Center for Catalytic Hydrocarbon Functionalizations(분자활성 촉매반응 연구단) > Journal Papers (저널논문)
Files in This Item:
2015-ChemAJ.pdfDownload

qrcode

  • facebook

    twitter

  • Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse