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Rootin, a compound that inhibits root development through modulating PIN-mediated auxin distribution

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Title
Rootin, a compound that inhibits root development through modulating PIN-mediated auxin distribution
Author(s)
Suyeong Jeong; Jun-Young Kim; Hyunmo Choi; Hyunmin Kim; Ilhwan Lee; Moon-Soo Soh; Hong Gil Nam; Young-Tae Chang; Pyung Ok Lim; Hye Ryun Woo
Publication Date
2015-04
Journal
PLANT SCIENCE, v.233, no., pp.116 - 126
Publisher
ELSEVIER IRELAND LTD
Abstract
tPlant roots anchor the plant to the soil and absorb water and nutrients for growth. Understanding themolecular mechanisms regulating root development is essential for improving plant survival and agricul-tural productivity. Extensive molecular genetic studies have provided important information on crucialcomponents for the root development control over the last few decades. However, it is becoming diffi-cult to identify new regulatory components in root development due to the functional redundancy andlethality of genes involved in root development. In this study, we performed a chemical genetic screen toidentify novel synthetic compounds that regulate root development in Arabidopsis seedlings. The screenyielded a root growth inhibitor designated as ‘rootin’, which inhibited Arabidopsis root development bymodulating cell division and elongation, but did not significantly affect shoot development. Transcriptanalysis of phytohormone marker genes revealed that rootin preferentially altered the expression ofauxin-regulated genes. Furthermore, rootin reduced the accumulation of PIN1, PIN3, and PIN7 proteins,and affected the auxin distribution in roots, which consequently may lead to the observed defects in rootdevelopment. Our results suggest that rootin could be utilized to unravel the mechanisms underlyingroot development and to investigate dynamic changes in PIN-mediated auxin distribution.
URI
https://pr.ibs.re.kr/handle/8788114/2061
ISSN
0168-9452
Appears in Collections:
Center for Plant Aging Research (식물 노화·수명 연구단) > Journal Papers (저널논문)
Center for Self-assembly and Complexity(복잡계 자기조립 연구단) > Journal Papers (저널논문)
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