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Actin remodelling factors control ciliogenesis by regulating YAP/TAZ activity and vesicle trafficking

Cited 72 time in webofscience Cited 85 time in scopus
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Title
Actin remodelling factors control ciliogenesis by regulating YAP/TAZ activity and vesicle trafficking
Author(s)
Jongshin Kim; Haiin Jo; Hyowon Hong; Min Hwan Kim; Jin Man Kim; June-Koo Lee; Won Do Heo; Joon Kim
Subject
Hippo Pathway, ; Primary Cilium, ; Growth-control, ; Cell-shape, ; Taz, ; Complex, ; Protein, ; NEK1, ; Yap, ; Activation
Publication Date
2015-04
Journal
NATURE COMMUNICATIONS, v.6, pp.6781
Publisher
NATURE PUBLISHING GROUP
Abstract
Primary cilia exert a profound impact on cell signalling and cell cycle progression. Recently, actin cytoskeleton destabilization has been recognized as a dominant inducer of ciliogenesis, but the exact mechanisms regulating ciliogenesis remain poorly understood. Here we show that the actin cytoskeleton remodelling controls ciliogenesis by regulating transcriptional coactivator YAP/TAZ as well as ciliary vesicle trafficking. Cytoplasmic retention of YAP/TAZ correlates with active ciliogenesis either in spatially confined cells or in cells treated with an actin filament destabilizer. Moreover, knockdown of YAP/TAZ is sufficient to induce ciliogenesis, whereas YAP/TAZ hyperactivation suppresses serum starvation-mediated ciliogenesis. We also identify actin remodelling factors LIMK2 and TESK1 as key players in the ciliogenesis control network in which YAP/TAZ and directional vesicle trafficking are integral components. Our work provides new insights for understanding the link between actin dynamics and ciliogenesis. © 2015 Macmillan Publishers Limited
URI
https://pr.ibs.re.kr/handle/8788114/2059
DOI
10.1038/ncomms7781
ISSN
2041-1723
Appears in Collections:
Center for Cognition and Sociality(인지 및 사회성 연구단) > 1. Journal Papers (저널논문)
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