Actin remodelling factors control ciliogenesis by regulating YAP/TAZ activity and vesicle trafficking

Cited 38 time in webofscience Cited 0 time in scopus
273 Viewed 122 Downloaded
Title
Actin remodelling factors control ciliogenesis by regulating YAP/TAZ activity and vesicle trafficking
Author(s)
Jongshin Kim; Haiin Jo; Hyowon Hong; Min Hwan Kim; Jin Man Kim; June-Koo Lee; Won Do Heo; Joon Kim
Publication Date
2015-04
Journal
NATURE COMMUNICATIONS, v.6, no., pp.6781 -
Publisher
NATURE PUBLISHING GROUP
Abstract
Primary cilia exert a profound impact on cell signalling and cell cycle progression. Recently, actin cytoskeleton destabilization has been recognized as a dominant inducer of ciliogenesis, but the exact mechanisms regulating ciliogenesis remain poorly understood. Here we show that the actin cytoskeleton remodelling controls ciliogenesis by regulating transcriptional coactivator YAP/TAZ as well as ciliary vesicle trafficking. Cytoplasmic retention of YAP/TAZ correlates with active ciliogenesis either in spatially confined cells or in cells treated with an actin filament destabilizer. Moreover, knockdown of YAP/TAZ is sufficient to induce ciliogenesis, whereas YAP/TAZ hyperactivation suppresses serum starvation-mediated ciliogenesis. We also identify actin remodelling factors LIMK2 and TESK1 as key players in the ciliogenesis control network in which YAP/TAZ and directional vesicle trafficking are integral components. Our work provides new insights for understanding the link between actin dynamics and ciliogenesis. © 2015 Macmillan Publishers Limited
URI
https://pr.ibs.re.kr/handle/8788114/2059
ISSN
2041-1723
Appears in Collections:
Center for Cognition and Sociality(인지 및 사회성 연구단) > Journal Papers (저널논문)
Files in This Item:
20150407_NATURE COMMUNICATIONS.pdfDownload

qrcode

  • facebook

    twitter

  • Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse