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면역 미생물 공생 연구단
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TAGLN2 regulates T cell activation by stabilizing the actin cytoskeleton at the immunological synapse

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Title
TAGLN2 regulates T cell activation by stabilizing the actin cytoskeleton at the immunological synapse
Author(s)
Na BR; Kim HR; Piragyte I; Oh HM; Kwon MS; Akber U; Lee HS; Do-Sim Park; Song WK; Park ZY; Sin-Hyeog Im; Rho MC; Hyun YM; Kim M; Jun CD
Publication Date
2015-04
Journal
JOURNAL OF CELL BIOLOGY, v.209, no.1, pp.143 - 162
Publisher
ROCKEFELLER UNIV PRESS
Abstract
The formation of an immunological synapse (IS) requires tight regulation of actin dynamics by many actin polymerizing/depolymerizing proteins. However, the significance of actin stabilization at the IS remains largely unknown. In this paper, we identify a novel function of TAGLN2.an actin-binding protein predominantly expressed in T cells.in stabilizing cortical F-actin, thereby maintaining F-actin contents at the IS and acquiring LFA-1 (leukocyte function-associated antigen-1) activation after T cell receptor stimulation. TAGLN2 blocks actin depolymerization and competes with cofilin both in vitro and in vivo. Knockout of TAGLN2 (TAGLN2/) reduced F-actin content and destabilized F-actin ring formation, resulting in decreased cell adhesion and spreading. TAGLN2/ T cells displayed weakened cytokine production and cytotoxic effector function. These findings reveal a novel function of TAGLN2 in enhancing T cell responses by controlling actin stability at the IS.
URI
http://pr.ibs.re.kr/handle/8788114/2052
DOI
10.1083/jcb.201407130
ISSN
0021-9525
Appears in Collections:
Academy of Immunology and Microbiology(면역 미생물 공생 연구단) > Journal Papers (저널논문)
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