Imaging deep within a scattering medium using collective accumulation of single-scattered waves

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Title
Imaging deep within a scattering medium using collective accumulation of single-scattered waves
Author(s)
Sungsam Kang; Seungwon Jeong; Wonjun Choi; Hakseok Ko; Taeseok D. Yang; Jang Ho Joo; Jae-Seung Lee; Yong-Sik Lim; Q-Han Park; Wonshik Choi
Publication Date
2015-04
Journal
NATURE PHOTONICS, v.9, no.4, pp.253 - 258
Publisher
NATURE PUBLISHING GROUP
Abstract
Optical microscopy suffers from a loss of resolving power when imaging targets are embedded in thick scattering media because of the dominance of strong multiple-scattered waves over waves scattered only a single time by the targets. Here, we present an approach that maintains full optical resolution when imaging deep within scattering media. We use both time-gated detection and spatial input–output correlation to identify those reflected waves that conserve in-plane momentum, which is a property of single-scattered waves. By implementing a superradiance-like collective accumulation of the single-scattered waves, we enhance the ratio of the single scattering signal to the multiple scattering background by more than three orders of magnitude. An imaging depth of 11.5 times the scattering mean free path is achieved with a near-diffraction-limited resolution of 1.5 μm. Our method of distinguishing single- from multiple-scattered waves will open new routes to deep-tissue imaging and studying the physics of the interaction of light with complex media.
URI
https://pr.ibs.re.kr/handle/8788114/2049
ISSN
1749-4885
Appears in Collections:
Center for Molecular Spectroscopy and Dynamics(분자 분광학 및 동력학 연구단) > Journal Papers (저널논문)
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