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분자활성 촉매반응 연구단
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Ru(II)-Catalyzed Site-Selective Hydroxylation of Flavone and Chromone Derivatives: The Importance of the 5-Hydroxyl Motif for the Inhibition of Aurora Kinases

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Title
Ru(II)-Catalyzed Site-Selective Hydroxylation of Flavone and Chromone Derivatives: The Importance of the 5-Hydroxyl Motif for the Inhibition of Aurora Kinases
Author(s)
Kiho Kim; Hyeonjeong Choe; Yujeong Jeong; Jun Hee Lee; Sungwoo Hong
Publication Date
2015-05
Journal
ORGANIC LETTERS, v.17, no.10, pp.2550 - 2553
Publisher
AMER CHEMICAL SOC
Abstract
An efficient protocol for Ru(II)-catalyzed direct C-H oxygenation of a broad range of flavone and chromone substrates was developed. This convenient and powerful synthetic tool allows for the rapid installation of the hydroxyl group into the flavone, chromone, and other related scaffolds and opens the way for analog synthesis of highly potent Aurora kinase inhibitors. The molecular docking simulations indicate that the formation of bidentate H-bonding patterns in the hinge regions between the 5-hydroxyflavonoids and Ala213 was the significant binding force, which is consistent with experimental and computational findings. © 2015 American Chemical Society. (Chemical Presented)
URI
https://pr.ibs.re.kr/handle/8788114/2027
ISSN
1523-7060
Appears in Collections:
Center for Catalytic Hydrocarbon Functionalizations(분자활성 촉매반응 연구단) > Journal Papers (저널논문)
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