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분자활성 촉매반응 연구단
분자활성 촉매반응 연구단
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RhI-catalyzed site-selective decarbonylative alkenylation and arylation of quinolones under chelation assistance

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Title
RhI-catalyzed site-selective decarbonylative alkenylation and arylation of quinolones under chelation assistance
Author(s)
Soonhyung Kwon; Dahye Kang; Sungwoo Hong
Publication Date
2015-06
Journal
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, v.2015, no.17, pp.3671 - 3678
Publisher
WILEY-V C H VERLAG GMBH
Abstract
An efficient catalytic system for the C-2 selective C-H functionalization of 4-quinolones was developed by using a decarbonylative coupling strategy. The installation of an N-pyrimidyl group on the quinolone nitrogen atom redirected the coordination between the catalyst and the carbonyl group to promote direct C-H functionalization at the 2-position of 4-quinolones. In addition, the present protocol was successfully applied to the C-3 selective installation of a variety of aryl and vinyl groups on an isoquinolone scaffold. The C-2 selective alkenylation and arylation reactions of 4-quinolones were achieved by using a RhI-catalyzed decarbonylative coupling strategy to afford valuable C-2 functionalized 4-quinolones. The present method was compatible with a broad scope of substrates and applied to the C-3 selective functionalization of an isoquinolone scaffold. Copyright © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
URI
https://pr.ibs.re.kr/handle/8788114/2009
ISSN
1434-193X
Appears in Collections:
Center for Catalytic Hydrocarbon Functionalizations(분자활성 촉매반응 연구단) > Journal Papers (저널논문)
Files in This Item:
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