BROWSE

Related Scientist

Researcher

뇌과학이미징연구단
뇌과학 이미징 연구단
more info

A mathematical model relating cortical oxygenated and deoxygenated hemoglobin flows and volumes to neural activity

Cited 0 time in webofscience Cited 0 time in scopus
312 Viewed 23 Downloaded
Title
A mathematical model relating cortical oxygenated and deoxygenated hemoglobin flows and volumes to neural activity
Author(s)
Cornelius, NR; Nishimura, N; Minah Suh; Schwartz, TH; Doerschuk, PC
Publication Date
2015-08
Journal
JOURNAL OF NEURAL ENGINEERING, v.12, no.4, pp.046013 -
Publisher
IOP PUBLISHING LTD
Abstract
Objective. To describe a toolkit of components for mathematical models of the relationship between cortical neural activity and space-resolved and time-resolved flows and volumes of oxygenated and deoxygenated hemoglobin motivated by optical intrinsic signal imaging (OISI). Approach. Both blood flow and blood volume and both oxygenated and deoxygenated hemoglobin and their interconversion are accounted for. Flow and volume are described by including analogies to both resistive and capacitive electrical circuit elements. Oxygenated and deoxygenated hemoglobin and their interconversion are described by generalization of Kirchhoff's laws based on well-mixed compartments. Main results. Mathematical models built from this toolkit are able to reproduce experimental single-stimulus OISI results that are described in papers from other research groups and are able to describe the response to multiple-stimuli experiments as a sublinear superposition of responses to the individual stimuli. Significance. The same assembly of tools from the toolkit but with different parameter values is able to describe effects that are considered distinctive, such as the presence or absence of an initial decrease in oxygenated hemoglobin concentration, indicating that the differences might be due to unique parameter values in a subject rather than different fundamental mechanisms
URI
https://pr.ibs.re.kr/handle/8788114/1952
ISSN
1741-2560
Appears in Collections:
Center for Neuroscience Imaging Research (뇌과학 이미징 연구단) > Journal Papers (저널논문)
Files in This Item:
19.A mathematical model relating cortical oxygenated and deoxygenated hemoglobin flows and volumes to neural activity.pdfDownload

qrcode

  • facebook

    twitter

  • Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse