Optogenetic control of cell signaling pathway through scattering skull using wavefront shaping

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Title
Optogenetic control of cell signaling pathway through scattering skull using wavefront shaping
Author(s)
Jonghee Yoon; Minji Lee; KyeoReh Lee; Nury Kim; Jin Man Kim; Jongchan Park; Hyeonseung Yu; Chulhee Choi; Won Do Heo; YongKeun Park
Publication Date
2015-08
Journal
SCIENTIFIC REPORTS, v.5, no., pp.13289 -
Publisher
NATURE PUBLISHING GROUP
Abstract
We introduce a non-invasive approach for optogenetic regulation in biological cells through highly scattering skull tissue using wavefront shaping. The wavefront of the incident light was systematically controlled using a spatial light modulator in order to overcome multiple light-scattering in a mouse skull layer and to focus light on the target cells. We demonstrate that illumination with shaped waves enables spatiotemporal regulation of intracellular Ca2+ level at the individual-cell level
URI
https://pr.ibs.re.kr/handle/8788114/1940
ISSN
2045-2322
Appears in Collections:
Center for Cognition and Sociality(인지 및 사회성 연구단) > Journal Papers (저널논문)
Files in This Item:
20150821_Scientific Reports.pdfDownload

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