BROWSE

Related Scientist

Researcher

면역미생물공생연구단
면역 미생물 공생 연구단
more info

Salmonella typhimurium Suppresses Tumor Growth via the Pro-Infammatory Cytokine Interleukin-1 beta

Cited 12 time in webofscience Cited 0 time in scopus
444 Viewed 852 Downloaded
Title
Salmonella typhimurium Suppresses Tumor Growth via the Pro-Infammatory Cytokine Interleukin-1 beta
Author(s)
Jung-Eun Kim; TX Phan; VH Nguyen; HV Dinh-Vu; JH Zheng; MS Yun; SG Park; YJ Hong; HE Choy; M Szardenings; Won Hwang; Jin-A Park; SunHee Park; Sin-Hyeog Im; JJ Min
Publication Date
2015-10
Journal
THERANOSTICS, v.5, no.12, pp.1328 - 1342
Publisher
IVYSPRING INT PUBL
Abstract
Although strains of attenuated Salmonella typhimurium and wild-type Escherichia coli show similar tumor-targeting capacities, only S. typhimurium significantly suppresses tumor growth in mice. The aim of the present study was to examine bacteria-mediated immune responses by conducting comparative analyses of the cytokine profiles and immune cell populations within tumor tissues colonized by E. coli or attenuated Salmonellae. CT26 tumor-bearing mice were treated with two different bacterial strains: S. typhimurium defective in ppGpp synthesis (ΔppGpp Salmonellae) or wild-type E. coli MG1655. Cytokine profiles and immune cell populations in tumor tissue colonized by these two bacterial strains were examined at two time points based on the pattern of tumor growth after ΔppGpp Salmonellae treatment: 1) when tumor growth was suppressed (‘suppression stage’) and 2) when they began to re-grow (‘re-growing stage’). The levels of IL-1β and TNF-α were markedly increased in tumors colonized by ΔppGpp Salmonellae. This increase was associated with tumor regression; the levels of both IL-1β and TNF-α returned to normal level when the tumors started to re-grow. To identify the immune cells primarily responsible for Salmonellae- mediated tumor suppression, we examined the major cell types that produce IL-1β and TNF-α. We found that macrophages and dendritic cells were the main producers of TNF-α and IL-1β. Inhibiting IL-1β production in Salmonellae-treated mice restored tumor growth, whereas tumor growth was suppressed for longer by local administration of recombinant IL-1β or TNF-α in conjunction with Salmonella therapy. These findings suggested that IL-1β and TNF-α play important roles in Salmonella-mediated cancer therapy. A better understanding of host immune responses in Salmonella therapy may increase the success of a given drug, particularly when various strategies are combined with bacteriotherapy. © 2015 Ivyspring International Publisher. Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited.
URI
http://pr.ibs.re.kr/handle/8788114/1867
DOI
10.7150/thno.11432
ISSN
1838-7640
Appears in Collections:
Academy of Immunology and Microbiology(면역 미생물 공생 연구단) > Journal Papers (저널논문)
Files in This Item:
(2015-Theranostics-Salmonella typhimurium Suppresses Tumor Growth via the Pro-Infammatory Cytokine Interleukin-1 beta).pdfDownload

qrcode

  • facebook

    twitter

  • Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse