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Role of the small subunit processome in the maintenance of pluripotent stem cells

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Title
Role of the small subunit processome in the maintenance of pluripotent stem cells
Author(s)
Kwon Tae You; Joha Park; V. Narry Kim
Publication Date
2015-10
Journal
GENES & DEVELOPMENT, v.29, no.19, pp.2004 - 2009
Publisher
COLD SPRING HARBOR LAB PRESS
Abstract
RNA-binding proteins (RBPs) play integral roles in gene regulation, yet only a small fraction of RBPs has been studied in the context of stem cells. Here we applied an RNAi screen for RBPs in mouse embryonic stemcells (ESCs) and identified 16 RBPs involved in pluripotency maintenance. Interestingly, six identified RBPs, including Krr1 and Ddx47, are part of a complex called small subunit processome (SSUP) that mediates 18S rRNA biogenesis. The SSUP components are preferentially expressed in stem cells and enhance the global translational rate, which is critical to sustain the protein levels of labile pluripotency factors such as Nanog and Esrrb. Furthermore, the SSUP proteins are required for efficient reprogramming of induced pluripotent stem cells. Our study uncovers the role of the SSUP and the importance of translational control in stem cell fate decision. © 2015 Dorn et al
URI
http://pr.ibs.re.kr/handle/8788114/1864
DOI
10.1101/gad.267112.115
ISSN
0890-9369
Appears in Collections:
Center for RNA Research(RNA 연구단) > Journal Papers (저널논문)
Files in This Item:
Genes Dev.-2015-You-2004-9.pdfDownload

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