BROWSE

Related Scientist

Researcher

RNA 연구단
RNA 연구단
more info

In-depth investigation of the interaction between DNA and nano-sized graphene oxide

Cited 17 time in webofscience Cited 0 time in scopus
425 Viewed 34 Downloaded
Title
In-depth investigation of the interaction between DNA and nano-sized graphene oxide
Author(s)
Jieon Lee; Yim, Y.; Kim, S.; Choi, M.-H.; Choi, B.-S.; Lee, Y.; Dal-Hee Min
Publication Date
2016-02
Journal
CARBON, v.97, no., pp.92 - 98
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Abstract
Graphene oxide (GO) has been harnessed in diverse biomedical applications such as drug delivery, biomolecule detection and enzymatic activity assay for a decade. In specific, optical biosensors have been developed based on the preferential binding of single stranded nucleic acid on GO and fluorescence quenching capability of GO. Recently, nano-size GO (NGO), which is smaller than micro-sized large GO (LGO), was employed for live cell imaging of various biomarkers and intracellular RNA. However, in contrast to the expanded applications of size controlled NGO, in-depth study on the interaction between DNA and NGO was not sufficiently carried out. Here, we investigated the DNA length dependent interaction between DNA and NGO. By using three DNA strands having different lengths, we observed (1) kinetics and capacity of DNA adsorption, (2) kinetics and sensitivity of sequence specific desorption of DNA and (3) relative strength of DNA interaction with NGO compared to LGO. Present study will give useful information on the effect of GO size to its interaction with DNA, which are important in developing robust biosensors based on GO and DNA. © 2015 Published by Elsevier Ltd
URI
https://pr.ibs.re.kr/handle/8788114/1816
ISSN
0008-6223
Appears in Collections:
Center for RNA Research(RNA 연구단) > Journal Papers (저널논문)
Files in This Item:
carbon.pdfDownload

qrcode

  • facebook

    twitter

  • Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse