NMDA receptor dysfunction in autism spectrum disorders

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Title
NMDA receptor dysfunction in autism spectrum disorders
Author(s)
Eun-Jae Lee; Su Yeon Choi; Eunjoon Kim
Publication Date
2015-02
Journal
CURRENT OPINION IN PHARMACOLOGY, v.20, no., pp.8 - 13
Publisher
ELSEVIER SCI LTD
Abstract
Abnormalities and imbalances in neuronal excitatory and inhibitory synapses have been implicated in diverse neuropsychiatric disorders including autism spectrum disorders (ASDs). Increasing evidence indicates that dysfunction of NMDA receptors (NMDARs) at excitatory synapses is associated with ASDs. In support of this, human ASD-associated genetic variations are found in genes encoding NMDAR subunits. Pharmacological enhancement or suppression of NMDAR function ameliorates ASD symptoms in humans. Animal models of ASD display bidirectional NMDAR dysfunction, and correcting this deficit rescues ASD-like behaviors. These findings suggest that deviation of NMDAR function in either direction contributes to the development of ASDs, and that correcting NMDAR dysfunction has therapeutic potential for ASDs.
URI
https://pr.ibs.re.kr/handle/8788114/1778
ISSN
1471-4892
Appears in Collections:
Center for Synaptic Brain Dysfunctions(시냅스 뇌질환 연구단) > Journal Papers (저널논문)
Files in This Item:
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