BROWSE

Related Scientist

kim,eunjoon's photo.

kim,eunjoon
시냅스뇌질환연구단
more info

ITEM VIEW & DOWNLOAD

NMDA receptor dysfunction in autism spectrum disorders

DC Field Value Language
dc.contributor.authorEun-Jae Lee-
dc.contributor.authorSu Yeon Choi-
dc.contributor.authorEunjoon Kim-
dc.date.available2015-09-01T01:20:02Z-
dc.date.created2015-02-16-
dc.date.issued2015-02-
dc.identifier.issn1471-4892-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/1778-
dc.description.abstractAbnormalities and imbalances in neuronal excitatory and inhibitory synapses have been implicated in diverse neuropsychiatric disorders including autism spectrum disorders (ASDs). Increasing evidence indicates that dysfunction of NMDA receptors (NMDARs) at excitatory synapses is associated with ASDs. In support of this, human ASD-associated genetic variations are found in genes encoding NMDAR subunits. Pharmacological enhancement or suppression of NMDAR function ameliorates ASD symptoms in humans. Animal models of ASD display bidirectional NMDAR dysfunction, and correcting this deficit rescues ASD-like behaviors. These findings suggest that deviation of NMDAR function in either direction contributes to the development of ASDs, and that correcting NMDAR dysfunction has therapeutic potential for ASDs.-
dc.description.uri1-
dc.language영어-
dc.publisherELSEVIER SCI LTD-
dc.titleNMDA receptor dysfunction in autism spectrum disorders-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid000349738600003-
dc.identifier.scopusid2-s2.0-84921980319-
dc.identifier.rimsid17586ko
dc.date.tcdate2018-10-01-
dc.contributor.affiliatedAuthorEunjoon Kim-
dc.identifier.doi10.1016/j.coph.2014.10.007-
dc.identifier.bibliographicCitationCURRENT OPINION IN PHARMACOLOGY, v.20, pp.8 - 13-
dc.citation.titleCURRENT OPINION IN PHARMACOLOGY-
dc.citation.volume20-
dc.citation.startPage8-
dc.citation.endPage13-
dc.date.scptcdate2018-10-01-
dc.description.wostc49-
dc.description.scptc50-
dc.description.journalClass1-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
Appears in Collections:
Center for Synaptic Brain Dysfunctions(시냅스 뇌질환 연구단) > 1. Journal Papers (저널논문)
Files in This Item:
2015_114.pdfDownload

qrcode

  • facebook

    twitter

  • Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse