The Structural Influence of Graphene Oxide on Its Fragmentation during Laser Desorption/Ionization Mass Spectrometry for Efficient Small-Molecule Analysis
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- The Structural Influence of Graphene Oxide on Its Fragmentation during Laser Desorption/Ionization Mass Spectrometry for Efficient Small-Molecule Analysis
- Young-Kwan Kim; Dal-Hee Min
- CHEMISTRY-A EUROPEAN JOURNAL, v.21, no.19, pp.7217 - 7223
- WILEY-V C H VERLAG GMBH
- The structural influence of graphene oxide (GO) on laser desorption/ionization mass spectrometry (LDI-MS) analysis of small molecules was systematically investigated by using size-fractionated GO. For fractionation of GO, pH-assisted centrifugation, sequential vacuum filtration, and sonochemical cutting processes were employed and the size-fractionated GO was thoroughly characterized to understand their size-dependent optochemical properties. Then, the fractionated GO was applied to the analysis of various small molecules by LDI-MS to investigate the relationship between their optochemical properties and LDI-MS performance. We found that large GO sheets (>0.5m) were more prone to fragmentation under laser irradiation during LDI-MS analysis than small GO sheets (<0.5m). In this regard, the LDI-MS analysis efficiency of various small molecules was significantly improved by using nanosized GO (NGO) as a matrix without background interference. In particular, NGO was successfully applied to the sensitive detection of hydrophobic pollutant molecules without requiring any surface-functionalization, enrichment, and separation process. Therefore, the present study could provide important basic information and be a practical tool for the development of simple and efficient LDI-MS platforms by using GO derivatives
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