BROWSE

Related Scientist

Researcher

RNA 연구단
RNA 연구단
more info

The Structural Influence of Graphene Oxide on Its Fragmentation during Laser Desorption/Ionization Mass Spectrometry for Efficient Small-Molecule Analysis

Cited 23 time in webofscience Cited 25 time in scopus
1,617 Viewed 145 Downloaded
Title
The Structural Influence of Graphene Oxide on Its Fragmentation during Laser Desorption/Ionization Mass Spectrometry for Efficient Small-Molecule Analysis
Author(s)
Young-Kwan Kim; Dal-Hee Min
Publication Date
2015-05
Journal
CHEMISTRY-A EUROPEAN JOURNAL, v.21, no.19, pp.7217 - 7223
Publisher
WILEY-V C H VERLAG GMBH
Abstract
The structural influence of graphene oxide (GO) on laser desorption/ionization mass spectrometry (LDI-MS) analysis of small molecules was systematically investigated by using size-fractionated GO. For fractionation of GO, pH-assisted centrifugation, sequential vacuum filtration, and sonochemical cutting processes were employed and the size-fractionated GO was thoroughly characterized to understand their size-dependent optochemical properties. Then, the fractionated GO was applied to the analysis of various small molecules by LDI-MS to investigate the relationship between their optochemical properties and LDI-MS performance. We found that large GO sheets (>0.5m) were more prone to fragmentation under laser irradiation during LDI-MS analysis than small GO sheets (<0.5m). In this regard, the LDI-MS analysis efficiency of various small molecules was significantly improved by using nanosized GO (NGO) as a matrix without background interference. In particular, NGO was successfully applied to the sensitive detection of hydrophobic pollutant molecules without requiring any surface-functionalization, enrichment, and separation process. Therefore, the present study could provide important basic information and be a practical tool for the development of simple and efficient LDI-MS platforms by using GO derivatives
URI
https://pr.ibs.re.kr/handle/8788114/1669
ISSN
0947-6539
Appears in Collections:
Center for RNA Research(RNA 연구단) > Journal Papers (저널논문)
Files in This Item:
7217_ftp.pdfDownload

qrcode

  • facebook

    twitter

  • Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse