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A new selective 'turn-on' small fluorescent cationic probe for recognition of RNA in cells

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Title
A new selective 'turn-on' small fluorescent cationic probe for recognition of RNA in cells
Author(s)
Nisar Ahmed; Bahareh Shirinfar; Vijay Madhav Miriyala; Seong-Kyoon Choi; Kyeong-Min Lee; Won Bae Jeon; Yu Shin Park; Hong Gil Nam
Publication Date
2015-07
Journal
SUPRAMOLECULAR CHEMISTRY, v.27, no.7-8, pp.478 - 483
Publisher
TAYLOR & FRANCIS LTD
Abstract
Fluorescent imaging probes have revolutionised cell biology by monitoring cellular objects. However, the lack of fluorescent probes with high selectivity for RNA has been a drawback. Thus, selective RNA binding for fluorescent sensors is essential. Here, we report the selective fluorescence enhancement upon addition of RNA. By exploiting a selective recognition of small tetra-cationic probe 1 for RNA, we also explain the possible binding mode for RNA. As a membranepermeant fluorescence probe, 1 provides selective imaging of RNA not only in human neuroblastoma tumour SH-SY5Y cell line used for Parkinson’s disease but also in the unicellular green alga cells. Further exploitation could open new opportunities in neurotoxin and cancer biology.
URI
https://pr.ibs.re.kr/handle/8788114/1621
ISSN
1061-0278
Appears in Collections:
Center for Plant Aging Research (식물 노화·수명 연구단) > Journal Papers (저널논문)
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2014_Supramolecular Chemistry.pdfDownload

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