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Gastric Organoid, a Promising Modeling for Gastric Stem Cell Homeostasis and Therapeutic Application

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Title
Gastric Organoid, a Promising Modeling for Gastric Stem Cell Homeostasis and Therapeutic Application
Author(s)
Lee, Subin; Jang-Hyun Choi; Park, So-Yeon; Jihoon Kim
Publication Date
2024-11
Journal
International Journal of Stem Cells, v.17, pp.337 - 346
Publisher
Korean Society for Stem Cell Research
Abstract
The elucidation of the pathophysiology underlying various diseases necessitates the development of research platforms that faithfully mimic in vivo conditions. Traditional model systems such as two-dimensional cell cultures and animal models have proven inadequate in capturing the complexities of human disease modeling. However, recent strides in organoid culture systems have opened up new avenues for comprehending gastric stem cell homeostasis and associated diseases, notably gastric cancer. Given the significance of gastric cancer, a thorough understanding of its pathophysiology and molecular underpinnings is imperative. To this end, the utilization of patient-derived organoid libraries emerges as a remarkable platform, as it faithfully mirrors patient-specific characteristics, including mutation profiles and drug sensitivities. Furthermore, genetic manipulation of gastric organoids facilitates the exploration of molecular mechanisms underlying gastric cancer development. This review provides a comprehensive overview of recent advancements in various adult stem cell-derived gastric organoid models and their diverse applications.
URI
https://pr.ibs.re.kr/handle/8788114/15587
DOI
10.15283/ijsc23075
ISSN
2005-3606
Appears in Collections:
Center for Genome Engineering(유전체 교정 연구단) > 1. Journal Papers (저널논문)
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