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A shifting role of thalamocortical connectivity in the emergence of cortical functional organization

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Title
A shifting role of thalamocortical connectivity in the emergence of cortical functional organization
Author(s)
Shinwon Park; Haak, Koen V.; Oldham, Stuart; Hanbyul Cho; Byeon, Kyoungseob; Bo-Yong Park; Thomson, Phoebe; Chen, Haitao; Gao, Wei; Xu, Ting; Valk, Sofie; Milham, Michael P.; Bernhardt, Boris; Di Martino, Adriana; Seok-Jun Hong
Publication Date
2024-08
Journal
Nature Neuroscience, v.27, pp.1609 - 1619
Publisher
Nature Publishing Group
Abstract
The cortical patterning principle has been a long-standing question in neuroscience, yet how this translates to macroscale functional specialization in the human brain remains largely unknown. Here we examine age-dependent differences in resting-state thalamocortical connectivity to investigate its role in the emergence of large-scale functional networks during early life, using a primarily cross-sectional but also longitudinal approach. We show that thalamocortical connectivity during infancy reflects an early differentiation of sensorimotor networks and genetically influenced axonal projection. This pattern changes in childhood, when connectivity is established with the salience network, while decoupling externally and internally oriented functional systems. A developmental simulation using generative network models corroborated these findings, demonstrating that thalamic connectivity contributes to developing key features of the mature brain, such as functional segregation and the sensory-association axis, especially across 12–18 years of age. Our study suggests that the thalamus plays an important role in functional specialization during development, with potential implications for studying conditions with compromised internal and external processing. © The Author(s), under exclusive licence to Springer Nature America, Inc. 2024.
URI
https://pr.ibs.re.kr/handle/8788114/15496
DOI
10.1038/s41593-024-01679-3
ISSN
1097-6256
Appears in Collections:
Center for Neuroscience Imaging Research (뇌과학 이미징 연구단) > 1. Journal Papers (저널논문)
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