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Abundance of the Membrane Proteome in Yeast Cells Lacking Spc1, a Non-catalytic Subunit of the Signal Peptidase Complex

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Title
Abundance of the Membrane Proteome in Yeast Cells Lacking Spc1, a Non-catalytic Subunit of the Signal Peptidase Complex
Author(s)
Yim, Chewon; Chung, Yeonji; Son, Sungjoon; Jeesoo Kim; Jong-Seo Kim; Kim, Hyun
Publication Date
2024-08
Journal
Journal of Membrane Biology, v.257, pp.207 - 214
Publisher
Springer Verlag
Abstract
The signal peptidase complex (SPC) mediates processing of signal peptides of secretory precursors. But, recent studies show that the eukaryotic SPC also cleaves internal transmembrane segments of some membrane proteins, and its non-catalytic subunit, Spc1/SPCS1 plays a critical role in this process. To assess the impact of Spc1 on membrane proteostasis, we carried out quantitative proteomics of yeast cells with and without Spc1. Our data show that the abundance of the membrane proteome in yeast cells lacking Spc1 is in general reduced compared to that in wild-type cells, implicating its role in controlling the cellular levels of membrane proteins.
URI
https://pr.ibs.re.kr/handle/8788114/15462
DOI
10.1007/s00232-024-00312-5
ISSN
0022-2631
Appears in Collections:
Center for RNA Research(RNA 연구단) > 1. Journal Papers (저널논문)
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