BROWSE

Related Scientist

cnir's photo.

cnir
뇌과학이미징연구단
more info

ITEM VIEW & DOWNLOAD

Brain representations of affective valence and intensity in sustained pleasure and pain

Cited 0 time in webofscience Cited 0 time in scopus
84 Viewed 0 Downloaded
Title
Brain representations of affective valence and intensity in sustained pleasure and pain
Author(s)
Soo Ahn Lee; Jae-Joong Lee; Han, Jisoo; Myunghwan Choi; Wager, Tor D.; Choong-Wan Woo
Publication Date
2024-06
Journal
Proceedings of the National Academy of Sciences of the United States of America, v.121, no.25, pp.e2310433121 - 10
Publisher
National Academy of Sciences
Abstract
Pleasure and pain are two fundamental, intertwined aspects of human emotions. Pleasurable sensations can reduce subjective feelings of pain and vice versa, and we often perceive the termination of pain as pleasant and the absence of pleasure as unpleasant. This implies the existence of brain systems that integrate them into modality-general representations of affective experiences. Here, we examined representations of affective valence and intensity in an functional MRI (fMRI) study (n = 58) of sustained pleasure and pain. We found that the distinct subpopulations of voxels within the ventromedial and lateral prefrontal cortices, the orbitofrontal cortex, the anterior insula, and the amygdala were involved in decoding affective valence versus intensity. Affective valence and intensity predictive models showed significant decoding performance in an independent test dataset (n = 62). These models were differentially connected to distinct large-scale brain networks-the intensity model to the ventral attention network and the valence model to the limbic and default mode networks. Overall, this study identified the brain representations of affective valence and intensity across pleasure and pain, promoting a systems-level understanding of human affective experiences.
URI
https://pr.ibs.re.kr/handle/8788114/15343
DOI
10.1073/pnas.2310433121
ISSN
0027-8424
Appears in Collections:
Center for Neuroscience Imaging Research (뇌과학 이미징 연구단) > 1. Journal Papers (저널논문)
Files in This Item:
There are no files associated with this item.

qrcode

  • facebook

    twitter

  • Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse