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Hypothalamic neuronal activation in non-human primates drives naturalistic goal-directed eating behavior

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Title
Hypothalamic neuronal activation in non-human primates drives naturalistic goal-directed eating behavior
Author(s)
Ha, Leslie Jaesun; Yeo, Hyeon-Gu; Kim, Yu Gyeong; Baek, Inhyeok; Baeg, Eunha; Lee, Young Hee; Won, Jinyoung; Jung, Yunkyo; Park, Junghyung; Jeon, Chang-Yeop; Kim, Keonwoo; Min, Jisun; Song, Youngkyu; Park, Jeong-Heon; Nam, Kyung Rok; Sangkyu Son; Seng Bum Michael Yoo; Park, Sung-hyun; Choi, Won Seok; Lim, Kyung Seob; Choi, Jae Yong; Cho, Jee-Hyun; Lee, Youngjeon; Choi, Hyung Jin
Publication Date
2024-07
Journal
Neuron, v.112, no.13, pp.2218 - 2230
Publisher
Cell Press
Abstract
Maladaptive feeding behavior is the primary cause of modern obesity. While the causal influence of the lateral hypothalamic area (LHA) on eating behavior has been established in rodents, there is currently no primate-based evidence available on naturalistic eating behaviors. We investigated the role of LHA GABAergic (LHAGABA) neurons in eating using chemogenetics in three macaques. LHAGABA neuron activation significantly increased naturalistic goal-directed behaviors and food motivation, predominantly for palatable food. Positron emission tomography and magnetic resonance spectroscopy validated chemogenetic activation. Resting-state functional magnetic resonance imaging revealed that the functional connectivity (FC) between the LHA and frontal areas was increased, while the FC between the frontal cortices was decreased after LHAGABA neuron activation. Thus, our study elucidates the role of LHAGABA neurons in eating and obesity therapeutics for primates and humans. © 2024 The Authors
URI
https://pr.ibs.re.kr/handle/8788114/15308
DOI
10.1016/j.neuron.2024.03.029
ISSN
0896-6273
Appears in Collections:
Center for Neuroscience Imaging Research (뇌과학 이미징 연구단) > 1. Journal Papers (저널논문)
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