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Smart Contact Lens for Colorimetric Visualization of Glucose Levels in the Body Fluid

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Title
Smart Contact Lens for Colorimetric Visualization of Glucose Levels in the Body Fluid
Author(s)
Seo, Jeongin; Kang, Jumi; Kim, Jungwoo; Han, Hyeju; Park, Minok; Mikyung Shin; Lee, Kyueui
Publication Date
2024-06
Journal
ACS Biomaterial Science & Engineering, v.10, no.6, pp.4035 - 4045
Publisher
American Chemical Society
Abstract
Frequent blood glucose monitoring is a crucial routine for diabetic patients. Traditional invasive methods can cause discomfort and pain and even pose a risk of infection. As a result, researchers have been exploring noninvasive techniques. However, a limited number of products have been developed for the market due to their high cost. In this study, we developed a low-cost, highly accessible, and noninvasive contact lens-based glucose monitoring system. We functionalized the surface of the contact lens with boronic acid, which has a strong but reversible binding affinity to glucose. To achieve facile conjugation of boronic acid, we utilized a functional coating layer called poly(tannic acid). The functionalized contact lens binds to glucose in body fluids (e.g., tear) and releases it when soaked in an enzymatic cocktail, allowing for the glucose level to be quantified through a colorimetric assay. Importantly, the transparency and oxygen permeability of the contact lens, which are crucial for practical use, were maintained after functionalization, and the lenses showed high biocompatibility. Based on the analysis of colorimetric data generated by the smartphone application and ultraviolet-visible (UV-vis) spectra, we believe that this contact lens has a high potential to be used as a smart diagnostic tool for monitoring and managing blood glucose levels.
URI
https://pr.ibs.re.kr/handle/8788114/15279
DOI
10.1021/acsbiomaterials.4c00431
Appears in Collections:
Center for Neuroscience Imaging Research (뇌과학 이미징 연구단) > 1. Journal Papers (저널논문)
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