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Extracorporeal Blood Treatment Using Functional Magnetic Nanoclusters Mitigates Organ Dysfunction of Sepsis in Swine

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dc.contributor.authorPark, Sung Jin-
dc.contributor.authorPark, Inwon-
dc.contributor.authorKim, Suhyun-
dc.contributor.authorKim, Min Kyu-
dc.contributor.authorKim, Seonghye-
dc.contributor.authorJeong, Hwain-
dc.contributor.authorKim, Dongsung-
dc.contributor.authorCho, Seung Woo-
dc.contributor.authorPark, Tae-Eun-
dc.contributor.authorNi, Aleksey-
dc.contributor.authorLim, Hankwon-
dc.contributor.authorJinmyoung Joo-
dc.contributor.authorLee, Jae Hyuk-
dc.contributor.authorKang, Joo H.-
dc.date.accessioned2024-05-27T05:30:10Z-
dc.date.available2024-05-27T05:30:10Z-
dc.date.created2024-01-08-
dc.date.issued2023-05-
dc.identifier.issn2366-9608-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/15189-
dc.description.abstractMitigating sepsis-induced severe organ dysfunction with magnetic nanoparticles has shown remarkable advances in extracorporeal blood treatment. Nevertheless, treating large septic animals remains challenging due to insufficient magnetic separation at rapid blood flow rates (>6 L h−1) and limited incubation time in an extracorporeal circuit. Herein, superparamagnetic nanoclusters (SPNCs) coated with red blood cell (RBC) membranes are developed, which promptly capture and magnetically separate a wide range of pathogens at high blood flow rates in a swine sepsis model. The SPNCs exhibited an ultranarrow size distribution of clustered iron oxide nanocrystals and exceptionally high saturation magnetization (≈ 90 emu g−1) close to that of bulk magnetite. It is also revealed that CD47 on the RBCs allows the RBC-SPNCs to remain at a consistent concentration in the blood by evading innate immunity. The uniform size distribution of the RBC-SPNCs greatly enhances their effectiveness in eradicating various pathogenic materials in extracorporeal blood. The use of RBC-SPNCs for extracorporeal treatment of swine infected with multidrug-resistant E. coli is validated and found that severe bacteremic sepsis-induced organ dysfunction is significantly mitigated after 12 h. The findings highlight the potential application of RBC-SPNCs for extracorporeal therapy of severe sepsis in large animal models and potentially humans. © 2023 Wiley-VCH GmbH.-
dc.language영어-
dc.publisherWILEY-V C H VERLAG GMBH-
dc.titleExtracorporeal Blood Treatment Using Functional Magnetic Nanoclusters Mitigates Organ Dysfunction of Sepsis in Swine-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid001134518600001-
dc.identifier.scopusid2-s2.0-85180913330-
dc.identifier.rimsid82378-
dc.contributor.affiliatedAuthorJinmyoung Joo-
dc.identifier.doi10.1002/smtd.202301428-
dc.identifier.bibliographicCitationSmall Methods, v.8, no.5-
dc.relation.isPartOfSmall Methods-
dc.citation.titleSmall Methods-
dc.citation.volume8-
dc.citation.number5-
dc.description.journalClass1-
dc.description.journalClass1-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalWebOfScienceCategoryChemistry, Physical-
dc.relation.journalWebOfScienceCategoryNanoscience & Nanotechnology-
dc.relation.journalWebOfScienceCategoryMaterials Science, Multidisciplinary-
dc.subject.keywordPlusPURIFICATION THERAPY-
dc.subject.keywordPlusHUMAN ENDOTOXEMIA-
dc.subject.keywordPlusREMOVAL-
dc.subject.keywordAuthorcell-camouflaged magnetic nanoclusters-
dc.subject.keywordAuthorextracorporeal blood-cleansing treatment-
dc.subject.keywordAuthorrestoring organ function-
dc.subject.keywordAuthorsepsis treatments-
dc.subject.keywordAuthorAMR-
Appears in Collections:
Center for Genomic Integrity(유전체 항상성 연구단) > 1. Journal Papers (저널논문)
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