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No replication of direct neuronal activity-related (DIANA) fMRI in anesthetized mice

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Title
No replication of direct neuronal activity-related (DIANA) fMRI in anesthetized mice
Author(s)
Sang-Han Choi; Geun Ho Im; Choi, Sangcheon; Yu, Xin; Bandettini, Peter A.; Menon, Ravi S.; Seong-Gi Kim
Publication Date
2024-03
Journal
Science Advances, v.10, no.13
Publisher
American Association for the Advancement of Science
Abstract
Direct imaging of neuronal activity (DIANA) by functional magnetic resonance imaging (fMRI) could be a revolutionary approach for advancing systems neuroscience research. To independently replicate this observation, we performed fMRI experiments in anesthetized mice. The blood oxygenation level-dependent (BOLD) response to whisker stimulation was reliably detected in the primary barrel cortex before and after DIANA experiments; however, no DIANA-like fMRI peak was observed in individual animals' data with the 50 to 300 trials. Extensively averaged data involving 1050 trials in six mice showed a flat baseline and no detectable neuronal activity-like fMRI peak. However, spurious, nonreplicable peaks were found when using a small number of trials, and artifactual peaks were detected when some outlier-like trials were excluded. Further, no detectable DIANA peak was observed in the BOLD-responding thalamus from the selected trials with the neuronal activity-like reference function in the barrel cortex. Thus, we were unable to replicate the previously reported results without data preselection.
URI
https://pr.ibs.re.kr/handle/8788114/15135
DOI
10.1126/sciadv.adl0999
Appears in Collections:
Center for Neuroscience Imaging Research (뇌과학 이미징 연구단) > 1. Journal Papers (저널논문)
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