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Sticky and Strain-Gradient Artificial Epineurium for Sutureless Nerve Repair in Rodents and Nonhuman Primates

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Title
Sticky and Strain-Gradient Artificial Epineurium for Sutureless Nerve Repair in Rodents and Nonhuman Primates
Author(s)
Duhwan Seong; Choi, Yeonsun; Choi, In Cheul; Jaebeom Lee; Choi, Jae Hyuk; Park, Ji Hun; Nam, Jae Jun; Jaewon Ju; Ryoo, Hyun Jae; Kwak, Donghee; Joonyeol Lee; Seong-Gi Kim; Kim, Dong Hwee; Park, Jong Woong; Mikyung Shin; Donghee Son
Publication Date
2024-04
Journal
Advanced Materials, v.36, no.16
Publisher
WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Abstract
The need for the development of soft materials capable of stably adhering to nerve tissues without any suturing followed by additional damages is at the fore at a time when success in postoperative recovery depends largely on the surgical experience and/or specialized microsuturing skills of the surgeon. Despite fully recognizing such prerequisite conditions, designing the materials with robust adhesion to wet nerves as well as acute/chronic anti-inflammation remains to be resolved. Herein, a sticky and strain-gradient artificial epineurium (SSGAE) that overcomes the most critically challenging aspect for realizing sutureless repair of severely injured nerves is presented. In this regard, the SSGAE with a skin-inspired hierarchical structure entailing strain-gradient layers, anisotropic Janus layers including hydrophobic top and hydrophilic bottom surfaces, and synergistic self-healing capabilities enables immediate and stable neurorrhaphy in both rodent and nonhuman primate models, indicating that the bioinspired materials strategy significantly contributes to translational medicine for effective peripheral nerve repair. A key feature in the materials design of wet adhesive, "a sticky and strain-gradient artificial epineurium (SSGAE) with skin-inspired hierarchical structure entailing strain-gradient layers, Janus hydrophilic/hydrophobic surfaces, and even self-healing property", which enables immediate and stable neurorrhaphy, is reported. image
URI
https://pr.ibs.re.kr/handle/8788114/15109
DOI
10.1002/adma.202307810
ISSN
0935-9648
Appears in Collections:
Center for Neuroscience Imaging Research (뇌과학 이미징 연구단) > 1. Journal Papers (저널논문)
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