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Inflammasome diversity: exploring novel frontiers in the innate immune response

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Title
Inflammasome diversity: exploring novel frontiers in the innate immune response
Author(s)
Yu, Gyeongju; Young Ki Choi; Lee, SangJoon
Publication Date
2024-04
Journal
Trends in Immunology, v.45, no.4, pp.248 - 258
Publisher
Elsevier BV
Abstract
Pathogens elicit complex mammalian immune responses by activating multiple sensors within inflammasomes, which recognize diverse pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs). This simultaneous activation induces the formation of protein complexes referred to as multiple inflammasomes, that orchestrate a spectrum of programmed cell death pathways, including pyroptosis, apoptosis, and necroptosis. This concept is crucial for comprehending the complexity of the innate immune system's response to diverse pathogens and its implications for various diseases. Novel contributions here include emphasizing simultaneous sensor activation by pathogens, proposing the existence of multiple inflammasome complexes, and advocating for further exploration of their structural basis. Understanding these mechanisms may offer insights into disease pathogenesis, paving the way for potential therapeutic interventions targeting inflammasome-mediated immune responses. © 2024 Elsevier Ltd
URI
https://pr.ibs.re.kr/handle/8788114/15085
DOI
10.1016/j.it.2024.02.004
ISSN
1471-4906
Appears in Collections:
Korea Virus Research Institute(한국바이러스기초연구소) > Center for Study of Emerging and Re-emerging Viruses(신변종 바이러스 연구센터) > 1. Journal Papers (저널논문)
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