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Versatile human cardiac tissues engineered with perfusable heart extracellular microenvironment for biomedical applications

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dc.contributor.authorSungjin Min-
dc.contributor.authorSuran Kim-
dc.contributor.authorWoo-Sup Sim-
dc.contributor.authorYi Sun Choi-
dc.contributor.authorHyebin Joo-
dc.contributor.authorJae-Hyun Park-
dc.contributor.authorSu-Jin Lee-
dc.contributor.authorHyeok Kim-
dc.contributor.authorMi Jeong Lee-
dc.contributor.authorInhea Jeong-
dc.contributor.authorBaofang Cui-
dc.contributor.authorSung-Hyun Jo-
dc.contributor.authorJin-Ju Kim-
dc.contributor.authorSeok Beom Hong-
dc.contributor.authorYeon-Jik Choi-
dc.contributor.authorKiwon Ban-
dc.contributor.authorYun-Gon Kim-
dc.contributor.authorJang-Ung Park-
dc.contributor.authorHyang-Ae Lee-
dc.contributor.authorHun-Jun Park-
dc.contributor.authorSeung-Woo Cho-
dc.date.accessioned2024-04-17T07:30:23Z-
dc.date.available2024-04-17T07:30:23Z-
dc.date.created2024-04-01-
dc.date.issued2024-03-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/15079-
dc.description.abstractEngineered human cardiac tissues have been utilized for various biomedical applications, including drug testing, disease modeling, and regenerative medicine. However, the applications of cardiac tissues derived from human pluripotent stem cells are often limited due to their immaturity and lack of functionality. Therefore, in this study, we establish a perfusable culture system based on in vivo-like heart microenvironments to improve human cardiac tissue fabrication. The integrated culture platform of a microfluidic chip and a three-dimensional heart extracellular matrix enhances human cardiac tissue development and their structural and functional maturation. These tissues are comprised of cardiovascular lineage cells, including cardiomyocytes and cardiac fibroblasts derived from human induced pluripotent stem cells, as well as vascular endothelial cells. The resultant macroscale human cardiac tissues exhibit improved efficacy in drug testing (small molecules with various levels of arrhythmia risk), disease modeling (Long QT Syndrome and cardiac fibrosis), and regenerative therapy (myocardial infarction treatment). Therefore, our culture system can serve as a highly effective tissue-engineering platform to provide human cardiac tissues for versatile biomedical applications. © The Author(s) 2024.; The application of engineered cardiac tissues is limited due to their immaturity and lack of functionality. Here, the authors develop an integrated culture platform featuring heart extracellular matrix cultured in a microfluidic chip to facilitate cardiac tissue development for versatile biomedical applications. © The Author(s) 2024.-
dc.language영어-
dc.publisherNature Publishing Group-
dc.titleVersatile human cardiac tissues engineered with perfusable heart extracellular microenvironment for biomedical applications-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid001189441500032-
dc.identifier.scopusid2-s2.0-85188441483-
dc.identifier.rimsid82845-
dc.contributor.affiliatedAuthorJang-Ung Park-
dc.contributor.affiliatedAuthorSeung-Woo Cho-
dc.identifier.doi10.1038/s41467-024-46928-y-
dc.identifier.bibliographicCitationNature Communications, v.15, no.1-
dc.relation.isPartOfNature Communications-
dc.citation.titleNature Communications-
dc.citation.volume15-
dc.citation.number1-
dc.description.journalClass1-
dc.description.journalClass1-
dc.description.isOpenAccessY-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
Appears in Collections:
Center for Nanomedicine (나노의학 연구단) > 1. Journal Papers (저널논문)
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