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Feasibility of high-resolution perfusion imaging using arterial spin labeling MRI at 3 Tesla

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Title
Feasibility of high-resolution perfusion imaging using arterial spin labeling MRI at 3 Tesla
Author(s)
Kashyap, Sriranga; Oliveira, icaro Agenor Ferreira; Kamil Uludag
Publication Date
2024-01
Journal
Frontiers in Physiology, v.14
Publisher
Frontiers Media S.A.
Abstract
Cerebral blood flow (CBF) is a critical physiological parameter of brain health, and it can be non-invasively measured with arterial spin labeling (ASL) MRI. In this study, we evaluated and optimized whole-brain, high-resolution ASL as an alternative to the low-resolution ASL employed in the routine assessment of CBF in both healthy participants and patients. Two high-resolution protocols (i.e., pCASL and FAIR-Q2TIPS (PASL) with 2 mm isotropic voxels) were compared to a default clinical pCASL protocol (3.4 x 3.4 x 4 mm3), all of whom had an acquisition time of approximate to 5 min. We assessed the impact of high-resolution acquisition on reducing partial voluming and improving sensitivity to the perfusion signal, and evaluated the effectiveness of z-deblurring on the ASL data. We compared the quality of whole-brain ASL acquired using three available head coils with differing number of receive channels (i.e., 20, 32, and 64ch). We found that using higher coil counts (32 and 64ch coils as compared to 20ch) offers improved signal-to-noise ratio (SNR) and acceleration capabilities that are beneficial for ASL imaging at 3 Tesla (3 T). The inherent reduction in partial voluming effects with higher resolution acquisitions improves the resolving power of perfusion without impacting the sensitivity. In conclusion, our results suggest that high-resolution ASL (2 to 2.5 mm isotropic voxels) has the potential to become a new standard for perfusion imaging at 3 T and increase its adoption into clinical research and cognitive neuroscience applications.
URI
https://pr.ibs.re.kr/handle/8788114/14969
DOI
10.3389/fphys.2023.1271254
ISSN
1664-042X
Appears in Collections:
Center for Neuroscience Imaging Research (뇌과학 이미징 연구단) > 1. Journal Papers (저널논문)
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