Spatiotemporal Control of Fibroblast Growth Factor Receptor Signals by Blue Light

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Title
Spatiotemporal Control of Fibroblast Growth Factor Receptor Signals by Blue Light
Author(s)
Nury Kim; Jin Man Kim; Minji Lee; Cha Yeon Kim; Ki-Young Chang; Won Do Heo
Publication Date
2014-07
Journal
CHEMISTRY & BIOLOGY, v.21, no.7, pp.903 - 912
Publisher
CELL PRESS
Abstract
Fibroblast growth factor receptors (FGFRs) regulate diverse cellular behaviors that should be exquisitely controlled in space and time. We engineered an optically controlled FGFR (optoFGFR1) by exploiting cryptochrome 2, which homointeracts upon blue light irradiation. OptoFGFR1 can rapidly and reversibly control intracellular FGFR1 signaling within seconds by illumination with blue light. At the subcellular level, localized activation of optoFGFR1 induced cytoskeletal reorganization. Utilizing the high spatiotemporal precision of optoFGFR1, we efficiently controlled cell polarity and induced directed cell migration. OptoFGFR1 provides an effective means to precisely control FGFR signaling and is an important optogenetic tool that can be used to study diverse biological processes both in vitro and in vivo. © 2014 Elsevier Ltd. All rights reserved.
URI
https://pr.ibs.re.kr/handle/8788114/1490
ISSN
1074-5521
Appears in Collections:
Center for Cognition and Sociality(인지 및 사회성 연구단) > Journal Papers (저널논문)
Files in This Item:
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