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Activated somatostatin interneurons orchestrate memory microcircuits

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Title
Activated somatostatin interneurons orchestrate memory microcircuits
Author(s)
Kim, TaeHyun; Choi, Dong Il; Choi, Ja Eun; Hoonwon Lee; Hyunsu Jung; Jooyoung Kim; Yongmin Sung; HyoJin Park; Kim, Min Jung; Dae Hee Han; Seung-Hee Lee; Bong-Kiun Kaang
Publication Date
2024-01
Journal
Neuron, v.112, no.2, pp.201 - 208.e4
Publisher
Cell Press
Abstract
Despite recent advancements in identifying engram cells, our understanding of their regulatory and functional mechanisms remains in its infancy. To provide mechanistic insight into engram cell functioning, we introduced a novel local microcircuit labeling technique that enables the labeling of intraregional synaptic connections. Utilizing this approach, we discovered a unique population of somatostatin (SOM) interneurons in the mouse basolateral amygdala (BLA). These neurons are activated during fear memory formation and exhibit a preference for forming synapses with excitatory engram neurons. Post-activation, these SOM neurons displayed varying excitability based on fear memory retrieval. Furthermore, when we modulated these SOM neurons chemogenetically, we observed changes in the expression of fear-related behaviors, both in a fear-associated context and in a novel setting. Our findings suggest that these activated SOM interneurons play a pivotal role in modulating engram cell activity. They influence the expression of fear-related behaviors through a mechanism that is dependent on memory cues. © 2023 Elsevier Inc.
URI
https://pr.ibs.re.kr/handle/8788114/14764
DOI
10.1016/j.neuron.2023.10.013
ISSN
0896-6273
Appears in Collections:
Center for Synaptic Brain Dysfunctions(시냅스 뇌질환 연구단) > 1. Journal Papers (저널논문)
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