BROWSE

Related Scientist

seunghee,lee's photo.

seunghee,lee
시냅스뇌질환연구단
more info

ITEM VIEW & DOWNLOAD

Activated somatostatin interneurons orchestrate memory microcircuits

DC Field Value Language
dc.contributor.authorKim, TaeHyun-
dc.contributor.authorChoi, Dong Il-
dc.contributor.authorChoi, Ja Eun-
dc.contributor.authorHoonwon Lee-
dc.contributor.authorHyunsu Jung-
dc.contributor.authorJooyoung Kim-
dc.contributor.authorYongmin Sung-
dc.contributor.authorHyoJin Park-
dc.contributor.authorKim, Min Jung-
dc.contributor.authorDae Hee Han-
dc.contributor.authorSeung-Hee Lee-
dc.contributor.authorBong-Kiun Kaang-
dc.date.accessioned2024-02-01T22:00:31Z-
dc.date.available2024-02-01T22:00:31Z-
dc.date.created2023-12-11-
dc.date.issued2024-01-
dc.identifier.issn0896-6273-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/14764-
dc.description.abstractDespite recent advancements in identifying engram cells, our understanding of their regulatory and functional mechanisms remains in its infancy. To provide mechanistic insight into engram cell functioning, we introduced a novel local microcircuit labeling technique that enables the labeling of intraregional synaptic connections. Utilizing this approach, we discovered a unique population of somatostatin (SOM) interneurons in the mouse basolateral amygdala (BLA). These neurons are activated during fear memory formation and exhibit a preference for forming synapses with excitatory engram neurons. Post-activation, these SOM neurons displayed varying excitability based on fear memory retrieval. Furthermore, when we modulated these SOM neurons chemogenetically, we observed changes in the expression of fear-related behaviors, both in a fear-associated context and in a novel setting. Our findings suggest that these activated SOM interneurons play a pivotal role in modulating engram cell activity. They influence the expression of fear-related behaviors through a mechanism that is dependent on memory cues. © 2023 Elsevier Inc.-
dc.language영어-
dc.publisherCell Press-
dc.titleActivated somatostatin interneurons orchestrate memory microcircuits-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid001164340700001-
dc.identifier.scopusid2-s2.0-85177771720-
dc.identifier.rimsid82181-
dc.contributor.affiliatedAuthorHoonwon Lee-
dc.contributor.affiliatedAuthorHyunsu Jung-
dc.contributor.affiliatedAuthorJooyoung Kim-
dc.contributor.affiliatedAuthorYongmin Sung-
dc.contributor.affiliatedAuthorHyoJin Park-
dc.contributor.affiliatedAuthorDae Hee Han-
dc.contributor.affiliatedAuthorSeung-Hee Lee-
dc.contributor.affiliatedAuthorBong-Kiun Kaang-
dc.identifier.doi10.1016/j.neuron.2023.10.013-
dc.identifier.bibliographicCitationNeuron, v.112, no.2, pp.201 - 208.e4-
dc.relation.isPartOfNeuron-
dc.citation.titleNeuron-
dc.citation.volume112-
dc.citation.number2-
dc.citation.startPage201-
dc.citation.endPage208.e4-
dc.description.journalClass1-
dc.description.journalClass1-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.subject.keywordAuthorbasolateral amygdala-
dc.subject.keywordAuthordual-eGRASP-
dc.subject.keywordAuthorfear memory-
dc.subject.keywordAuthorfear-related behaviors-
dc.subject.keywordAuthorLCD-GRASP-
dc.subject.keywordAuthormicrocircuit-
dc.subject.keywordAuthorsomatostatin interneuron-
Appears in Collections:
Center for Synaptic Brain Dysfunctions(시냅스 뇌질환 연구단) > 1. Journal Papers (저널논문)
Files in This Item:
There are no files associated with this item.

qrcode

  • facebook

    twitter

  • Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse