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Sarcoma Immunotherapy: Confronting Present Hurdles and Unveiling Upcoming Opportunities

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Title
Sarcoma Immunotherapy: Confronting Present Hurdles and Unveiling Upcoming Opportunities
Author(s)
Sehan Jeong; Afroz, Sharmin; Donghyun Kang; Jeonghwan Noh; Jooyeon Suh; Kim, June Hyuk; You, Hye Jin; Kang, Hyun Guy; Kim, Yi-Jun; Jin-Hong Kim
Publication Date
2023-10
Journal
Molecules and Cells, v.46, no.10, pp.579 - 588
Publisher
한국분자세포생물학회
Abstract
Sarcomas are rare and heterogeneous mesenchymal neoplasms originating from the bone or soft tissues, which pose significant treatment challenges. The current standard treatment for sarcomas consists of surgical resection, often combined with chemo- and radiotherapy; however, local recurrence and metastasis remain significant concerns. Although immunotherapy has demonstrated promise in improving long-term survival rates for certain cancers, sarcomas are generally considered to be relatively less immunogenic than other tumors, presenting substantial challenges for effective immunotherapy. In this review, we examine the possible opportunities for sarcoma immunotherapy, noting cancer testis antigens expressed in sarcomas. We then cover the current status of immunotherapies in sarcomas, including progress in cancer vaccines, immune checkpoint inhibitors, and adoptive cellular therapy and their potential in combating these tumors. Furthermore, we discuss the limitations of immunotherapies in sarcomas, including a low tumor mutation burden and immunosuppressive tumor microenvironment, and explore potential strategies to tackle the immunosuppressive barriers in therapeutic interventions, shedding light on the development of effective and personalized treatments for sarcomas. Overall, this review provides a comprehensive overview of the current status and potential of immunotherapies in sarcoma treatment, highlighting the challenges and opportunities for developing effective therapies to improve the outcomes of patients with these rare malignancies.
URI
https://pr.ibs.re.kr/handle/8788114/14471
DOI
10.14348/molcells.2023.0079
ISSN
1016-8478
Appears in Collections:
Center for RNA Research(RNA 연구단) > 1. Journal Papers (저널논문)
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