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Joana Collares Pereira Almaca
식물 노화·수명 연구단
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Young capillary vessels rejuvenate aged pancreatic islets

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Title
Young capillary vessels rejuvenate aged pancreatic islets
Author(s)
Joana Almaca; Molina, J; Drigo, RAE; Abdulreda, MH; Jeon, WB; Berggren, PO; Caicedo, A; Hong Gil Nam
Publication Date
2014-12
Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v.111, no.49, pp.17612 - 17617
Publisher
NATL ACAD SCIENCES
Abstract
Pancreatic islets secrete hormones that play a key role in regulating blood glucose levels (glycemia). Age-dependent impairment of islet function and concomitant dysregulation of glycemia are major health threats in aged populations. However, the major causes of the age-dependent decline of islet function are still disputed. Here we demonstrate that aging of pancreatic islets in mice and humans is notably associated with inflammation and fibrosis of islet blood vessels but does not affect glucose sensing and the insulin secretory capacity of islet beta cells. Accordingly, when transplanted into the anterior chamber of the eye of young mice with diabetes, islets from old mice are revascularized with healthy blood vessels, show strong islet cell proliferation, and fully restore control of glycemia. Our results indicate that beta cell function does not decline with age and suggest that islet function is threatened by an age-dependent impairment of islet vascular function. Strategies to mitigate age-dependent dysregulation in glycemia should therefore target systemic and/or local inflammation and fibrosis of the aged islet vasculature.
URI
https://pr.ibs.re.kr/handle/8788114/1440
ISSN
0027-8424
Appears in Collections:
Center for Plant Aging Research (식물 노화·수명 연구단) > Journal Papers (저널논문)
Files in This Item:
PNAS-2014-Alma--1414053111.pdfDownload

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