BROWSE

Related Scientist

's photo.

인지및사회성연구단
more info

ITEM VIEW & DOWNLOAD

Reward learning improves social signal processing in autism model mice

Cited 0 time in webofscience Cited 0 time in scopus
94 Viewed 0 Downloaded
Title
Reward learning improves social signal processing in autism model mice
Author(s)
Joowon Kim; Min Whan Jung; Doyun Lee
Publication Date
2023-10
Journal
Cell Reports, v.42, no.10
Publisher
Elsevier B.V.
Abstract
Social and reward signal processing and their association are critical elements of social motivation. Despite the use of reward learning to improve the social interactions of patients with autism spectrum disorder (ASD), the underlying neural mechanisms are unknown. Here, we found different yet conjunct neuronal representations of social and reward signals in the mouse medial prefrontal cortex (mPFC). We also found that social signal processing is selectively disrupted, whereas reward signal processing is intact in the mPFC of Shank2-knockout mice, a mouse model of ASD. Furthermore, reward learning not only allows Shank2-knockout mice to associate social stimuli with reward availability, but it also rescues the impaired social signal processing. These findings provide insights into the neural basis for the therapeutic use of reward learning in ASD.
URI
https://pr.ibs.re.kr/handle/8788114/14296
DOI
10.1016/j.celrep.2023.113228
ISSN
2211-1247
Appears in Collections:
Center for Cognition and Sociality(인지 및 사회성 연구단) > 1. Journal Papers (저널논문)
Center for Synaptic Brain Dysfunctions(시냅스 뇌질환 연구단) > 1. Journal Papers (저널논문)
Files in This Item:
There are no files associated with this item.

qrcode

  • facebook

    twitter

  • Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse