Developmental retardation, microcephaly, and peptiduria in mice without aminopeptidase P1

Cited 3 time in webofscience Cited 0 time in scopus
543 Viewed 80 Downloaded
Title
Developmental retardation, microcephaly, and peptiduria in mice without aminopeptidase P1
Author(s)
Sang Ho Yoon; Young-Soo Bae; Mi-Sun Mun; Kyeong-Yeol Park; Sang-Kyu Ye; Eunjoon Kim; Myoung-Hwan Kim
Publication Date
2012-12
Journal
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.429, no.3-4, pp.204 - 209
Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
Abstract
Cytosolic aminopeptidase P1 (APP1) is one of the three known mammalian aminopeptidase Ps (APPs) that cleave the N-terminal amino acid residue of peptides in which the penultimate amino acid is proline. In mammals, many biologically active peptides have a highly conserved N-terminal penultimate proline. However, little is known about the physiological role of APP1. In addition, there is no direct evidence to associate a deficiency in APP1 with metabolic diseases. Although two human subjects with reduced APP activity exhibited peptiduria, it is unclear which of the three APP isoforms is responsible for this disorder. In this study, we generated APP1-deficient mice by knocking out Xpnpep1. Mouse APP1 deficiency causes severe growth retardation, microcephaly, and modest lethality. In addition, imino-oligopeptide excretion was observed in urine samples from APP1-deficient mice. These results suggest an essential role for APP1-mediated peptide metabolism in body and brain development, and indicate a strong causal link between APP1 deficiency and peptiduria. (C) 2012 Elsevier Inc. All rights reserved.
URI
https://pr.ibs.re.kr/handle/8788114/1420
ISSN
0006-291X
Appears in Collections:
Center for Synaptic Brain Dysfunctions(시냅스 뇌질환 연구단) > Journal Papers (저널논문)
Files in This Item:
2012_101.pdfDownload

qrcode

  • facebook

    twitter

  • Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse