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시냅스뇌질환연구단
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Developmental retardation, microcephaly, and peptiduria in mice without aminopeptidase P1

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dc.contributor.authorSang Ho Yoon-
dc.contributor.authorYoung-Soo Bae-
dc.contributor.authorMi-Sun Mun-
dc.contributor.authorKyeong-Yeol Park-
dc.contributor.authorSang-Kyu Ye-
dc.contributor.authorEunjoon Kim-
dc.contributor.authorMyoung-Hwan Kim-
dc.date.available2015-04-20T07:24:26Z-
dc.date.created2014-09-30-
dc.date.issued2012-12-
dc.identifier.issn0006-291X-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/1420-
dc.description.abstractCytosolic aminopeptidase P1 (APP1) is one of the three known mammalian aminopeptidase Ps (APPs) that cleave the N-terminal amino acid residue of peptides in which the penultimate amino acid is proline. In mammals, many biologically active peptides have a highly conserved N-terminal penultimate proline. However, little is known about the physiological role of APP1. In addition, there is no direct evidence to associate a deficiency in APP1 with metabolic diseases. Although two human subjects with reduced APP activity exhibited peptiduria, it is unclear which of the three APP isoforms is responsible for this disorder. In this study, we generated APP1-deficient mice by knocking out Xpnpep1. Mouse APP1 deficiency causes severe growth retardation, microcephaly, and modest lethality. In addition, imino-oligopeptide excretion was observed in urine samples from APP1-deficient mice. These results suggest an essential role for APP1-mediated peptide metabolism in body and brain development, and indicate a strong causal link between APP1 deficiency and peptiduria. (C) 2012 Elsevier Inc. All rights reserved.-
dc.description.uri1-
dc.language영어-
dc.publisherACADEMIC PRESS INC ELSEVIER SCIENCE-
dc.subjectAminopeptidase P1 (APP1), Developmental retardation, Microcephaly, Peptiduria, Xpnpep1 Knockout, APP1 deficiency-
dc.titleDevelopmental retardation, microcephaly, and peptiduria in mice without aminopeptidase P1-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid000312514200014-
dc.identifier.scopusid2-s2.0-84870702727-
dc.identifier.rimsid5154ko
dc.date.tcdate2018-10-01-
dc.contributor.affiliatedAuthorYoung-Soo Bae-
dc.contributor.affiliatedAuthorEunjoon Kim-
dc.identifier.doi10.1016/j.bbrc.2012.10.104-
dc.identifier.bibliographicCitationBIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.429, no.3-4, pp.204 - 209-
dc.citation.titleBIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS-
dc.citation.volume429-
dc.citation.number3-4-
dc.citation.startPage204-
dc.citation.endPage209-
dc.date.scptcdate2018-10-01-
dc.description.wostc3-
dc.description.scptc3-
dc.description.journalClass1-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
Appears in Collections:
Center for Synaptic Brain Dysfunctions(시냅스 뇌질환 연구단) > 1. Journal Papers (저널논문)
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