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Magneto-acoustic protein nanostructures for non-invasive imaging of tissue mechanics in vivo

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Title
Magneto-acoustic protein nanostructures for non-invasive imaging of tissue mechanics in vivo
Author(s)
Whee-Soo Kim; Sungjin Min; Su Kyeom Kim; Sunghwi Kang; Soohwan An; Ernesto Criado-Hidalgo; Hunter Davis; Avinoam Bar-Zion; Dina Malounda; Yu Heun Kim; Jae-Hyun Lee; Soo Han Bae; Jin Gu Lee; Minsuk Kwak; Seung-Woo Cho; Mikhail G. Shapiro; Jinwoo Cheon
Publication Date
2024-02
Journal
Nature Materials, v.23, pp.290 - 300
Publisher
Nature Publishing Group
Abstract
Measuring cellular and tissue mechanics inside intact living organisms is essential for interrogating the roles of force in physiological and disease processes. Current agents for studying the mechanobiology of intact, living organisms are limited by poor light penetration and material stability. Magnetomotive ultrasound is an emerging modality for real-time in vivo imaging of tissue mechanics. Nonetheless, it has poor sensitivity and spatiotemporal resolution. Here we describe magneto-gas vesicles (MGVs), protein nanostructures based on gas vesicles and magnetic nanoparticles that produce differential ultrasound signals in response to varying mechanical properties of surrounding tissues. These hybrid nanomaterials significantly improve signal strength and detection sensitivity. Furthermore, MGVs enable non-invasive, long-term and quantitative measurements of mechanical properties within three-dimensional tissues and in vivo fibrosis models. Using MGVs as novel contrast agents, we demonstrate their potential for non-invasive imaging of tissue elasticity, offering insights into mechanobiology and its application to disease diagnosis and treatment.
URI
https://pr.ibs.re.kr/handle/8788114/14136
DOI
10.1038/s41563-023-01688-w
ISSN
1476-1122
Appears in Collections:
Center for Nanomedicine (나노의학 연구단) > 1. Journal Papers (저널논문)
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