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Human CD8+ T-Cell Populations That Express Natural Killer Receptors

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Title
Human CD8+ T-Cell Populations That Express Natural Killer Receptors
Author(s)
Koh, June-Young; Kim, Dong-Uk; Moon, Bae-Hyeon; Eui-Cheol Shin
Publication Date
2023-02
Journal
Immune Network, v.23, no.1
Publisher
대한면역학회
Abstract
CD8+ T cells are activated by TCRs that recognize specific cognate Ags, while NK-cell activation is regulated by a balance between signals from germline-encoded activating and inhibitory NK receptors. Through these different processes of Ag recognition, CD8+ T cells and NK cells play distinct roles as adaptive and innate immune cells, respectively. However, some human CD8+ T cells have been found to express activating or inhibitory NK receptors. CD8+ T-cell populations expressing NK receptors straddle the innate-adaptive boundary with their innate-like features. Recent breakthrough technical advances in multi-omics analysis have enabled elucidation of the unique immunologic characteristics of these populations. However, studies have not yet fully clarified the heterogeneity and immunological characteristics of each CD8+ T-cell population expressing NK receptors. Here we aimed to review the current knowledge of various CD8+ T-cell populations expressing NK receptors, and to pave the way for delineating the landscape and identifying the various roles of these T-cell populations. © 2023, Korean Association of Immunologists. All rights reserved.
URI
https://pr.ibs.re.kr/handle/8788114/14008
DOI
10.4110/in.2023.23.e8
ISSN
1598-2629
Appears in Collections:
Korea Virus Research Institute(한국바이러스기초연구소) > Center for Viral Immunology(바이러스 면역 연구센터) > 1. Journal Papers (저널논문)
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