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SARS-CoV-2 mRNA Vaccine Elicits Sustained T Cell Responses Against the Omicron Variant in Adolescents

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Title
SARS-CoV-2 mRNA Vaccine Elicits Sustained T Cell Responses Against the Omicron Variant in Adolescents
Author(s)
Choi, Sujin; Sang-Hoon Kim; Han, Mi Seon; Yoon, Yoonsun; Kim, Yun-Kyung; Cho, Hye-Kyung; Yun, Ki Wook; Song, Seung Ha; Ahn, Bin; Kim, Ye Kyung; Choi, Sung Hwan; Choe, Young June; Lim, Heeji; Choi, Eun Bee; Kim, Kwangwook; Hyeon, Seokhwan; Lim, Hye Jung; Kim, Byung-chul; Lee, Yoo-kyoung; Choi, Eun Hwa; Eui-Cheol Shin; Lee, Hyunju
Publication Date
2023-08
Journal
Immune Network, v.23, no.4
Publisher
대한면역학회
Abstract
Vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been acknowledged as an effective mean of preventing infection and hospitalization. However, the emergence of highly transmissible SARS-CoV-2 variants of concern (VOCs) has led to substantial increase in infections among children and adolescents. Vaccine induced immunity and longevity have not been well defined in this population. Therefore, we aimed to analyze humoral and cellular immune responses against ancestral and SARSCoV-2 variants after two shots of the BNT162b2 vaccine in healthy adolescents. Although vaccination induced a robust increase of spike-specific binding Abs and neutralizing Abs against the ancestral and SARS-CoV-2 variants, the neutralizing activity against the Omicron variant was significantly low. On the contrary, vaccine-induced memory CD4+ T cells exhibited substantial responses against both ancestral and Omicron spike proteins. Notably, CD4+ T cell responses against both ancestral and Omicron strains were preserved at 3 months after two shots of the BNT162b2 vaccine without waning. Polyfunctionality of vaccine-induced memory T cells was also preserved in response to Omicron spike protein. The present findings characterize the protective immunity of vaccination for adolescents in the era of continuous emergence of variants/subvariants.
URI
https://pr.ibs.re.kr/handle/8788114/14000
DOI
10.4110/in.2023.23.e33
ISSN
1598-2629
Appears in Collections:
Korea Virus Research Institute(한국바이러스기초연구소) > Center for Viral Immunology(바이러스 면역 연구센터) > 1. Journal Papers (저널논문)
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