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Nucleophilic C4-selective (hetero) arylation of pyridines for facile synthesis of heterobiaryls

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Title
Nucleophilic C4-selective (hetero) arylation of pyridines for facile synthesis of heterobiaryls
Author(s)
Kewon Kim; Euna You; Sungwoo Hong
Publication Date
2023-09
Journal
Frontiers in Chemistry, v.11
Publisher
Frontiers Media SA
Abstract
The synthesis of heterobiaryl compounds holds significant value in organic chemistry due to their extensive range of applications. Herein, we report a highly efficient strategy for conducting C4-selective (hetero) arylation of pyridines using N-aminopyridinium salts. The reaction proceeds readily at room temperature in the presence of a base, thus eliminating the requirement for catalysts or oxidants. This method allows for the installation of various electron-rich (hetero) aryl groups on pyridines, resulting in the streamlined synthesis of highly valuable C4-(hetero) aryl pyridine derivatives, which are otherwise challenging to acquire via conventional methods. This simple and straightforward method will facilitate access to a range of heterobiaryl compounds thereby promoting their application in various scientific disciplines. Copyright © 2023 Kim, You and Hong.
URI
https://pr.ibs.re.kr/handle/8788114/13994
DOI
10.3389/fchem.2023.1254632
ISSN
2296-2646
Appears in Collections:
Center for Catalytic Hydrocarbon Functionalizations(분자활성 촉매반응 연구단) > 1. Journal Papers (저널논문)
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