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유전체항상성연구단
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Experimental systems for the analysis of mutational signatures: no 'one-size-fits-all' solution

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Title
Experimental systems for the analysis of mutational signatures: no 'one-size-fits-all' solution
Author(s)
Dmitri Ivanov; Hwang, Taejoo; Lukasz Karol Sitko; Lee, Semin; Anton Gartner
Publication Date
2023-06
Journal
BIOCHEMICAL SOCIETY TRANSACTIONS, v.51, no.3, pp.1307 - 1317
Publisher
PORTLAND PRESS LTD
Abstract
Cells constantly accumulate mutations, which are caused by replication errors, as well as through the action of endogenous and exogenous DNA-damaging agents. Mutational patterns reflect the status of DNA repair machinery and the history of genotoxin exposure of a given cellular clone. Computationally derived mutational signatures can shed light on the origins of cancer. However, to understand the etiology of cancer signatures, they need to be compared with experimental signatures, which are obtained from the isogenic cell lines or organisms under controlled conditions. Experimental mutational patterns were instrumental in understanding the nature of signatures caused by mismatch repair and BRCA deficiencies. Here, we describe how different cell lines and model organisms were used in recent years to decipher mutational signatures observed in cancer genomes and provide examples of how data from different experimental systems complement and support each other.
URI
https://pr.ibs.re.kr/handle/8788114/13648
DOI
10.1042/BST20221482
ISSN
0300-5127
Appears in Collections:
Center for Genomic Integrity(유전체 항상성 연구단) > 1. Journal Papers (저널논문)
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