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Brain-wide mapping reveals that engrams for a single memory are distributed across multiple brain regionsHighly Cited Paper

DC Field Value Language
dc.contributor.authorDheeraj S. Roy-
dc.contributor.authorYoung-Gyun Park-
dc.contributor.authorMinyoung E. Kim-
dc.contributor.authorYing Zhang-
dc.contributor.authorSachie K. Ogawa-
dc.contributor.authorNicholas DiNapoli-
dc.contributor.authorXinyi Gu-
dc.contributor.authorJae H. Cho-
dc.contributor.authorHeejin Choi-
dc.contributor.authorLee Kamentsky-
dc.contributor.authorJared Martin-
dc.contributor.authorOlivia Mosto-
dc.contributor.authorTomomi Aida-
dc.contributor.authorKwanghun Chung-
dc.contributor.authorSusumu Tonegawa-
dc.date.accessioned2023-04-05T22:01:51Z-
dc.date.available2023-04-05T22:01:51Z-
dc.date.created2023-03-28-
dc.date.issued2022-04-
dc.identifier.issn2041-1723-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/13181-
dc.description.abstractNeuronal ensembles that hold specific memory (memory engrams) have been identified in the hippocampus, amygdala, or cortex. However, it has been hypothesized that engrams of a specific memory are distributed among multiple brain regions that are functionally connected, referred to as a unified engram complex. Here, we report a partial map of the engram complex for contextual fear conditioning memory by characterizing encoding activated neuronal ensembles in 247 regions using tissue phenotyping in mice. The mapping was aided by an engram index, which identified 117 cFos(+) brain regions holding engrams with high probability, and brain-wide reactivation of these neuronal ensembles by recall. Optogenetic manipulation experiments revealed engram ensembles, many of which were functionally connected to hippocampal or amygdala engrams. Simultaneous chemogenetic reactivation of multiple engram ensembles conferred a greater level of memory recall than reactivation of a single engram ensemble, reflecting the natural memory recall process. Overall, our study supports the unified engram complex hypothesis for memory storage. Where memories are located in our brains is not well understood. In this paper, the authors demonstrate that memories are spread out throughout multiple brain regions.-
dc.language영어-
dc.publisherNATURE PORTFOLIO-
dc.titleBrain-wide mapping reveals that engrams for a single memory are distributed across multiple brain regions-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid000778265300028-
dc.identifier.scopusid2-s2.0-85127513878-
dc.identifier.rimsid80310-
dc.contributor.affiliatedAuthorKwanghun Chung-
dc.identifier.doi10.1038/s41467-022-29384-4-
dc.identifier.bibliographicCitationNATURE COMMUNICATIONS, v.13, no.1-
dc.relation.isPartOfNATURE COMMUNICATIONS-
dc.citation.titleNATURE COMMUNICATIONS-
dc.citation.volume13-
dc.citation.number1-
dc.description.journalClass1-
dc.description.journalClass1-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalWebOfScienceCategoryMultidisciplinary Sciences-
dc.subject.keywordPlusRETRIEVAL-
dc.subject.keywordPlusCORTEX-
dc.subject.keywordPlusFEAR MEMORY-
dc.subject.keywordPlusCIRCUITS-
dc.subject.keywordPlusCELLS-
dc.subject.keywordPlusINTERROGATION-
Appears in Collections:
Center for Nanomedicine (나노의학 연구단) > 1. Journal Papers (저널논문)
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