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Ruthenium-catalyzed direct C-H amidation of arenes including weakly coordinating aromatic ketones

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Title: Ruthenium-catalyzed direct C-H amidation of arenes including weakly coordinating aromatic ketones

Subject: Amidation, ; Aromatic ketones, ; C-H activation, ; Heterocycles, ; Sulfonyl azides, ; Synthetic utility, ; Activation analysis, ; Amination, ; Catalysis, ; Ketones, ; Nitrogen compounds, ; Ruthenium, ; Aromatic compounds, ; alkene, ; azide, ; heterocyclic compound, ; ketone, ; ruthenium, ; article, ; catalysis, ; chemistry, ; hydrogen bond, ; synthesis, ; Alkenes, ; Azides, ; Catalysis, ; Heterocyclic Compounds, ; Hydrogen Bonding, ; Ketones, ; Ruthenium

Abstract: C-H activation: The ruthenium-catalyzed direct sp2 C-H amidation of arenes by using sulfonyl azides as the amino source is presented (see scheme). A wide range of substrates were readily amidated including arenes bearing weakly coordinating groups. Synthetic utility of the thus obtained products was demonstrated in the preparation of biologically active heterocycles. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.