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Long-range functional connections mirror and link microarchitectural and cognitive hierarchies in the human brain

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Title
Long-range functional connections mirror and link microarchitectural and cognitive hierarchies in the human brain
Author(s)
Wang, Yezhou; Royer, Jessica; Bo-Yong Park; de Wael, Reinder Vos; Lariviere, Sara; Tavakol, Shahin; Rodriguez-Cruces, Raul; Paquola, Casey; Seok-Jun Hong; Margulies, Daniel S.; Smallwood, Jonathan; Valk, Sofie L.; Evans, Alan C.; Bernhardt, Boris C.
Publication Date
2023-03
Journal
CEREBRAL CORTEX, v.33, no.5, pp.1782 - 1798
Publisher
OXFORD UNIV PRESS INC
Abstract
Background Higher-order cognition is hypothesized to be implemented via distributed cortical networks that are linked via long-range connections. However, it is unknown how computational advantages of long-range connections reflect cortical microstructure and microcircuitry. Methods We investigated this question by (i) profiling long-range cortical connectivity using resting-state functional magnetic resonance imaging (MRI) and cortico-cortical geodesic distance mapping, (ii) assessing how long-range connections reflect local brain microarchitecture, and (iii) examining the microarchitectural similarity of regions connected through long-range connections. Results Analysis of 2 independent datasets indicated that sensory/motor areas had more clustered short-range connections, while transmodal association systems hosted distributed, long-range connections. Meta-analytical decoding suggested that this topographical difference mirrored shifts in cognitive function, from perception/action towards emotional/social processing. Analysis of myelin-sensitive in vivo MRI as well as postmortem histology and transcriptomics datasets established that gradients in functional connectivity distance are paralleled by those present in cortical microarchitecture. Notably, long-range connections were found to link spatially remote regions of association cortex with an unexpectedly similar microarchitecture. Conclusions By mapping covarying topographies of long-range functional connections and cortical microcircuits, the current work provides insights into structure-function relations in human neocortex.
URI
https://pr.ibs.re.kr/handle/8788114/13133
DOI
10.1093/cercor/bhac172
ISSN
1047-3211
Appears in Collections:
Center for Neuroscience Imaging Research (뇌과학 이미징 연구단) > 1. Journal Papers (저널논문)
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