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Extra-Basal Ganglia Brain Structures Are Related to Motor Reserve in Parkinson's Disease

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Title
Extra-Basal Ganglia Brain Structures Are Related to Motor Reserve in Parkinson's Disease
Author(s)
Youn, Jinyoung; Ji Hye Won; Kim, Mansu; Junmo Kwon; Moon, Seung Hwan; Kim, Minkyeong; Ahn, Jong Hyun; Mun, Jun Kyu; Hyunjin Park; Cho, Jin Whan
Publication Date
2023-01
Journal
JOURNAL OF PARKINSONS DISEASE, v.13, no.1, pp.39 - 48
Publisher
IOS PRESS
Abstract
Background: The "motor reserve" is an emerging concept based on the discrepancy between the severity of parkinsonism and dopaminergic degeneration; however, the related brain structures have not yet been elucidated. Objective: We investigated brain structures relevant to the motor reserve in Parkinson's disease (PD) in this study. Methods: Patients with drug-naive, early PD were enrolled, who then underwent dopamine transporter (DAT) scan and diffusion tensor imaging (DTI). The severity of motor symptoms was evaluated with the Unified Parkinson's Disease Rating Scale score of bradykinesia and rigidity on the more affected side and dopaminergic degeneration of DAT uptake of the more affected putamen. Individual motor reserve estimate (MRE) was evaluated based on the discrepancy between the severity of motor symptoms and dopaminergic degeneration. Using DTI and the Brainnetome atlas, brain structures correlated with MRE were identified. Results: We enrolled 193 patients with drug-naive PD (mean disease duration of 15.6 +/- 13.2 months), and the MRE successfully predicted the increase of levodopa equivalent dose after two years. In the DTI analysis, fractional anisotropy values of medial, inferior frontal, and temporal lobes, limbic structures, nucleus accumbens, and thalamus were positively correlated with the MRE, while no brain structures were correlated with mean diffusivity. Additionally, degree centrality derived from the structural connectivity of the frontal and temporal lobes and limbic structures was positively correlated with the MRE. Conclusion: Our results show empirical evidence for MR in PD and brain structures relevant to MR, particularly, the extra-basal ganglia system including the limbic and frontal structures.
URI
https://pr.ibs.re.kr/handle/8788114/13113
DOI
10.3233/JPD-223542
ISSN
1877-7171
Appears in Collections:
Center for Neuroscience Imaging Research (뇌과학 이미징 연구단) > 1. Journal Papers (저널논문)
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