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Wireless Non-Invasive Monitoring of Cholesterol Using a Smart Contact Lens

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Title
Wireless Non-Invasive Monitoring of Cholesterol Using a Smart Contact Lens
Author(s)
Hayoung Song; Haein Shin; Hunkyu Seo; Wonjung Park; Byung Jun Joo; Jeongho Kim; Jeonghyun Kim; Hong Kyun Kim; Jayoung Kim; Jang-Ung Park
Publication Date
2022-10
Journal
ADVANCED SCIENCE, v.9, no.28
Publisher
WILEY
Abstract
Herein, a wireless and soft smart contact lens that enables real-time quantitative recording of cholesterol in tear fluids for the monitoring of patients with hyperlipidemia using a smartphone is reported. This contact lens incorporates an electrochemical biosensor for the continuous detection of cholesterol concentrations, stretchable antenna, and integrated circuits for wireless communication, which makes a smartphone the only device required to operate this lens remotely without obstructing the wearer's vision. The hyperlipidemia rabbit model is utilized to confirm the correlation between cholesterol levels in tear fluid and blood and to confirm the feasibility of this smart contact lens for diagnostic application of cholesterol-related diseases. Further in vivo tests with human subjects demonstrated its good biocompatibility, wearability, and reliability as a non-invasive healthcare device.
URI
https://pr.ibs.re.kr/handle/8788114/12827
DOI
10.1002/advs.202203597
ISSN
2198-3844
Appears in Collections:
Center for Nanomedicine (나노의학 연구단) > 1. Journal Papers (저널논문)
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