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Multimodal Characterization of Cardiac Organoids Using Integrations of Pressure-Sensitive Transistor Arrays with Three-Dimensional Liquid Metal Electrodes

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dc.contributor.authorMoohyun Kim-
dc.contributor.authorJae Chul Hwang-
dc.contributor.authorSungjin Min-
dc.contributor.authorYoung-Geun Park-
dc.contributor.authorSuran Kim-
dc.contributor.authorEnji Kim-
dc.contributor.authorHunkyu Seo-
dc.contributor.authorWon Gi Chung-
dc.contributor.authorJakyoung Lee-
dc.contributor.authorSeung-Woo Cho-
dc.contributor.authorJang-Ung Park-
dc.date.accessioned2023-01-26T02:41:22Z-
dc.date.available2023-01-26T02:41:22Z-
dc.date.created2022-10-29-
dc.date.issued2022-10-
dc.identifier.issn1530-6984-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/12680-
dc.description.abstractHerein, we present an unconventional method for multimodal characterization of three-dimensional cardiac organo-ids. This method can monitor and control the mechanophysio-logical parameters of organoids within a single device. In this method, local pressure distributions of human-induced pluripotent stem-cell-derived cardiac organoids are visualized spatiotemporally by an active-matrix array of pressure-sensitive transistors. This array is integrated with three-dimensional electrodes formed by the high-resolution printing of liquid metal. These liquid-metal electrodes are inserted inside an organoid to form the intra-organoid interface for simultaneous electrophysiological recording and stimulation. The low mechanical modulus and low impedance of the liquid-metal electrodes are compatible with organoids' soft biological tissue, which enables stable electric pacing at low thresholds. In contrast to conventional electrophysiological methods, this measurement of a cardiac organoid's beating pressures enabled simultaneous treatment of electrical therapeutics using a single device without any interference between the pressure signals and electrical pulses from pacing electrodes, even in wet organoid conditions.-
dc.language영어-
dc.publisherAMER CHEMICAL SOC-
dc.titleMultimodal Characterization of Cardiac Organoids Using Integrations of Pressure-Sensitive Transistor Arrays with Three-Dimensional Liquid Metal Electrodes-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid000861796300001-
dc.identifier.scopusid2-s2.0-85138988202-
dc.identifier.rimsid79085-
dc.contributor.affiliatedAuthorMoohyun Kim-
dc.contributor.affiliatedAuthorJae Chul Hwang-
dc.contributor.affiliatedAuthorYoung-Geun Park-
dc.contributor.affiliatedAuthorEnji Kim-
dc.contributor.affiliatedAuthorHunkyu Seo-
dc.contributor.affiliatedAuthorWon Gi Chung-
dc.contributor.affiliatedAuthorJakyoung Lee-
dc.contributor.affiliatedAuthorSeung-Woo Cho-
dc.contributor.affiliatedAuthorJang-Ung Park-
dc.identifier.doi10.1021/acs.nanolett.2c02790-
dc.identifier.bibliographicCitationNANO LETTERS, v.22, no.19, pp.7892 - 7901-
dc.relation.isPartOfNANO LETTERS-
dc.citation.titleNANO LETTERS-
dc.citation.volume22-
dc.citation.number19-
dc.citation.startPage7892-
dc.citation.endPage7901-
dc.type.docTypeArticle; Early Access-
dc.description.journalClass1-
dc.description.journalClass1-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaChemistry-
dc.relation.journalResearchAreaScience & Technology - Other Topics-
dc.relation.journalResearchAreaMaterials Science-
dc.relation.journalResearchAreaPhysics-
dc.relation.journalWebOfScienceCategoryChemistry, Multidisciplinary-
dc.relation.journalWebOfScienceCategoryChemistry, Physical-
dc.relation.journalWebOfScienceCategoryNanoscience & Nanotechnology-
dc.relation.journalWebOfScienceCategoryMaterials Science, Multidisciplinary-
dc.relation.journalWebOfScienceCategoryPhysics, Applied-
dc.relation.journalWebOfScienceCategoryPhysics, Condensed Matter-
dc.subject.keywordPlusGENERATION-
dc.subject.keywordPlusPLATFORM-
dc.subject.keywordAuthorbioelectronics-
dc.subject.keywordAuthorliquid metal-
dc.subject.keywordAuthorcardiac organoid-
dc.subject.keywordAuthorpressure sensor-
dc.subject.keywordAuthormultimodal characterization-
Appears in Collections:
Center for Nanomedicine (나노의학 연구단) > 1. Journal Papers (저널논문)
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