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복잡계자기조립연구단
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Visualizing inflammation with an M1 macrophage selective probe via GLUT1 as the gating target

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dc.contributor.authorCho, Heewon-
dc.contributor.authorHaw-Young Kwon-
dc.contributor.authorSharma, Amit-
dc.contributor.authorLee, Sun Hyeok-
dc.contributor.authorLiu, Xiao-
dc.contributor.authorNaoki Miyamoto-
dc.contributor.authorKim, Jong-Jin-
dc.contributor.authorIm, Sin-Hyeog-
dc.contributor.authorKang, Nam-Young-
dc.contributor.authorYoung-Tae Chang-
dc.date.accessioned2023-01-26T02:39:28Z-
dc.date.available2023-01-26T02:39:28Z-
dc.date.created2022-10-29-
dc.date.issued2022-10-
dc.identifier.issn2041-1723-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/12661-
dc.description.abstractStudying the specific roles of macrophage subsets has been hampered by a lack of subset-specific probes. Here the authors report an M1 selective fluorescent probe named CDr17, and demonstrate the suitability of this probe for tracking M1 macrophages in vivo. Macrophages play crucial roles in protecting our bodies from infection and cancers. As macrophages are multi-functional immune cells, they have diverse plastic subsets, such as M1 and M2, derived from naive M0 cells. Subset-specific macrophage probes are essential for deciphering and monitoring the various activation of macrophages, but developing such probes has been challenging. Here we report a fluorescent probe, CDr17, which is selective for M1 macrophages over M2 or M0. The selective staining mechanism of CDr17 is explicated as Gating-Oriented Live-cell Distinction (GOLD) through overexpressed GLUT1 in M1 macrophages. Finally, we demonstrate the suitability of CDr17 to track M1 macrophages in vivo in a rheumatoid arthritis animal model.-
dc.language영어-
dc.publisherNATURE PORTFOLIO-
dc.titleVisualizing inflammation with an M1 macrophage selective probe via GLUT1 as the gating target-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid000867457000025-
dc.identifier.scopusid2-s2.0-85139509172-
dc.identifier.rimsid79155-
dc.contributor.affiliatedAuthorHaw-Young Kwon-
dc.contributor.affiliatedAuthorNaoki Miyamoto-
dc.contributor.affiliatedAuthorYoung-Tae Chang-
dc.identifier.doi10.1038/s41467-022-33526-z-
dc.identifier.bibliographicCitationNATURE COMMUNICATIONS, v.13, no.1-
dc.relation.isPartOfNATURE COMMUNICATIONS-
dc.citation.titleNATURE COMMUNICATIONS-
dc.citation.volume13-
dc.citation.number1-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.journalClass1-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaScience & Technology - Other Topics-
dc.relation.journalWebOfScienceCategoryMultidisciplinary Sciences-
dc.subject.keywordPlusPOLARIZATION-
Appears in Collections:
Center for Self-assembly and Complexity(복잡계 자기조립 연구단) > 1. Journal Papers (저널논문)
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