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Coordinated cortical thickness alterations across six neurodevelopmental and psychiatric disorders

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Title
Coordinated cortical thickness alterations across six neurodevelopmental and psychiatric disorders
Author(s)
Hettwer, M.D.; Lariviere, S.; B.Y. Park; van, den Heuvel O.A.; Schmaal, L.; Andreassen, O.A.; Ching, C.R.K.; Hoogman, M.; Buitelaar, J.; van, Rooij D.; Veltman, D.J.; Stein, D.J.; Franke, B.; van, Erp T.G.M.; Jahanshad, N.; Thompson, P.M.; Thomopoulos, S.I.; Bethlehem, R.A.I.; Bernhardt, B.C.; Eickhoff, S.B.; Valk, S.L.
Publication Date
2022-11
Journal
Nature communications, v.13, no.1, pp.6851
Publisher
NLM (Medline)
Abstract
© 2022. The Author(s).Neuropsychiatric disorders are increasingly conceptualized as overlapping spectra sharing multi-level neurobiological alterations. However, whether transdiagnostic cortical alterations covary in a biologically meaningful way is currently unknown. Here, we studied co-alteration networks across six neurodevelopmental and psychiatric disorders, reflecting pathological structural covariance. In 12,024 patients and 18,969 controls from the ENIGMA consortium, we observed that co-alteration patterns followed normative connectome organization and were anchored to prefrontal and temporal disease epicenters. Manifold learning revealed frontal-to-temporal and sensory/limbic-to-occipitoparietal transdiagnostic gradients, differentiating shared illness effects on cortical thickness along these axes. The principal gradient aligned with a normative cortical thickness covariance gradient and established a transcriptomic link to cortico-cerebello-thalamic circuits. Moreover, transdiagnostic gradients segregated functional networks involved in basic sensory, attentional/perceptual, and domain-general cognitive processes, and distinguished between regional cytoarchitectonic profiles. Together, our findings indicate that shared illness effects occur in a synchronized fashion and along multiple levels of hierarchical cortical organization.
URI
https://pr.ibs.re.kr/handle/8788114/12591
DOI
10.1038/s41467-022-34367-6
ISSN
2041-1723
Appears in Collections:
Center for Neuroscience Imaging Research (뇌과학 이미징 연구단) > 1. Journal Papers (저널논문)
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